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In the Epstein laboratory, we are interested in molecular mechanisms of cardiovascular development and stem cell biology, and the implications for human disease. The lab has a longstanding history in pursuing the genetic causes of congenital heart disease and mechanisms of cell fate determination.
Our research combines biochemistry, cell biology, and genomics to determine how the three-dimensional organization of chromatin in the nucleus (“nuclear architecture”) contributes to cell identity and how cell differentiation is regulated by protein complexes that tether regions of the genome to the nuclear periphery. Most recently, we have focused on epigenetics, including the role of histone deacetylases in cardiac development and adult heart function. The lab has pioneered the concept that entire gene programs, such as those defining cardiac cell types, can be regulated through interactions between the nuclear lamina and chromatin. Current studies are underway to determine the factors regulating 3D chromatin organization as the cell advances through the cell cycle and as it undergoes differentiation.
The Epstein lab discovered the tumor suppressor and stem cell gene Hopx and continues to study its role in the heart and in numerous tissue-specific adult resident stem cells including those in the central nervous system, the intestine and the skin.
Finally, the lab is using novel methods of engineering immune cells to develop proof-of-principle approaches for treating common cardiovascular disorders.
In the Epstein laboratory, we are interested in molecular mechanisms of cardiovascular development and stem cell biology, and the implications for human disease. The lab has a longstanding history in pursuing the genetic causes of congenital heart disease and mechanisms of cell fate determination.
Our research combines biochemistry, cell biology, and genomics to determine how the three-dimensional organization of chromatin in the nucleus (“nuclear architecture”) contributes to cell identity and how cell differentiation is regulated by protein complexes that tether regions of the genome to the nuclear periphery. Most recently, we have focused on epigenetics, including the role of histone deacetylases in cardiac development and adult heart function. The lab has pioneered the concept that entire gene programs, such as those defining cardiac cell types, can be regulated through interactions between the nuclear lamina and chromatin. Current studies are underway to determine the factors regulating 3D chromatin organization as the cell advances through the cell cycle and as it undergoes differentiation.
The Epstein lab discovered the tumor suppressor and stem cell gene Hopx and continues to study its role in the heart and in numerous tissue-specific adult resident stem cells including those in the central nervous system, the intestine and the skin.
Finally, the lab is using novel methods of engineering immune cells to develop proof-of-principle approaches for treating common cardiovascular disorders.
研究兴趣
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Blake Jardin,Jonathan A. Epstein
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGYno. 1 (2024): C107-C111
Science advancesno. 11 (2024): eadm9518-eadm9518
NATURE CARDIOVASCULAR RESEARCHpp.1-6, (2024)
Molecular Cancer Researchno. 5_Supplement (2023): IA17-IA17
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MOLECULAR CANCER RESEARCHno. 5 (2023)
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NATUREno. 7945 (2023): E5-E5
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