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个人简介
Jonathan’s research focuses on understanding the metabolic programs that promote tumor growth as well as the activation, differentiation, and function of immune cells. By defining divergent metabolic programs of tumor and immune cells, his group seeks to define new targets for inhibiting tumor growth and enhancing cancer immunotherapy.
During his 20 years at Johns Hopkins, Jonathan’s lab sought to understand how immune cells integrate signals from the immune micro-environment to promote differentiation and function. This work identified a critical role for mTOR in contributing to this process and focused on the metabolic programs that regulate immune responses to cancer. By targeting metabolism, his group was able to enhance the function of anti-tumor-specific T cells and inhibit the generation and function of inhibitory cells such as MDSCs (myeloid-derived suppressor cells). By continuing to pursue this line of inquiry at Calico, Jonathan hopes to define novel targets for cancer therapy.
研究兴趣
论文共 401 篇作者统计合作学者相似作者
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Megan L. Wood,Julie C. Fanburg-Smith, James M. Brian,Jason C. White,Jonathan L. Powell, Andrew S. Freiberg
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGYno. 2 (2024): e184-e187
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGYno. 2 (2024): e208-e211
Monali Praharaj, Fan Shen, Alex J Lee,Liang Zhao,Thomas R Nirschl,Debebe Theodros, Alok K Singh,Xiaoxu Wang, Kenneth M Adusei,Kara A Lombardo, Raekwon A Williams,Laura A Sena,
Cancer immunology research (2024)
Samuel L Collins,Yee Chan-Li, Kevin Shenderov, Astrid Gillich, Andrew M Nelson, Jeffrey M Loube, Wayne A Mitzner,Jonathan D Powell,Maureen R Horton
bioRxiv : the preprint server for biology (2024)
NURSING RESEARCHno. 2 (2024): 166-171
Natureno. 7946 (2023): E12-E14
Danielle E Arnold,Saara Kaviany,Jahnavi Aluri,Luis Murguia-Favela,Nicola A. Wright, Loughran Thomas P.,Jonathan Powell,Suk See De Ravin,V. Koneti Rao,Steven Holland,Jack Bleesing, Jeffrey J. Bednarski,
Blood (2023): 936
Cancer Researchno. 8_Supplement (2023): CT257-CT257
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PEDIATRIC BLOOD & CANCER (2023): S86-S87
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