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个人简介
Johnny Lisboa obtained his Master’s Degree in Biochemistry in 2010 by the University Pierre et Marie Curie (Paris, France). In 2013, he obtained his PhD on Biochemistry and Biophysics by University of Paris-Sud, under the supervision of Dr. Sophie Quevillon-Cheruel at the Institute for Integrative Biology of the Cell (I2BC, Paris). His PhD project focus in the structural and functional study of specific proteins involved in the natural transformation systems of various human pathogens, in order to understand their molecular mechanisms and interaction networks. Using X-ray crystallography and NMR as the main technical approach, complemented by a plethora of other biochemical, biophysical, and computational techniques, he has been studying the function of macromolecules and macromolecular complexes from their high-resolution structures. He also used powerful molecular tools for examining and characterizing protein-protein, protein-DNA, and protein-RNA interactions. He is currently involved in the functional and structural characterization of AIP56, an apoptogenic bacterial toxin from Photobacterium damselae subsp. piscicida (Phdp) that acts by targeting NF-kB (with two publications published and two in preparation). He has established collaborative work with another groups (Molecular Microbiology group- with one publication published to Nucleic Acid Research and Carlos Osorio group- with one publication), and participated in a variety of other projects involved in the characterization of novel virulence factors secreted by Phdp which is responsible for fish photobacteriosis. He has co-supervised and evaluated undergraduate students and has taken roles of lab management, budgeting and logistics. He also gave 5 oral presentation and 21 posters in national/international conferences, meetings, seminars and symposiums. He is currently interested in studying/characterizing new AIP56-related toxins to understand the mechanism of these new toxins and used them as alternative vehicles for antigen delivery.
研究兴趣
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bioRxiv (Cold Spring Harbor Laboratory) (2023)
Nature communicationsno. 1 (2023): 1-16
J. Lisboa,R. Pinto, I. S. Rodrigues, L. M. G. Pereira,C. Pereira,P. Oliveira,P. J. B. Pereira,D. Durand,R. Benz,A. do Vale,N. M. S. dos Santos
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Johnny Lisboa,Cassilda Pereira, Aline Rifflet,Juan Ayala,Mateus S. Terceti,Alba V. Barca, Inês Rodrigues,Pedro José Barbosa Pereira,Carlos R. Osorio, Francisco García-del Portillo, Ivo Gomperts Boneca,Ana do Vale,
mSphereno. 1 (2021)
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