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Bio
Professor John Chiang’s lab purified and cloned the gene of cholesterol 7-hydroxylase (CYP7A1) in bile acid synthesis in hepatocytes. He studied the molecular mechanisms of bile acid feedback regulation of CYP7A1 transcription by nuclear receptors and transcription factors. His original research lead to the identification of bile acid-activated nuclear receptor FXR and the gut to liver axis in regulation of bile acid synthesis. His current research projects are focused on the role and mechanism of FXR and TGR5 signaling in regulation of bile acid, glucose, lipid and energy metabolism in non-alcoholic fatty liver disease, obesity and diabetes, and therapeutic treatments. His research projects have been funded continuously by NIH grants for over 33 years and received a MERIT award from NIDDK, NIH. He is an editor of Hepatology, Hepatology Communications and Gene Expression, and Executive Associate editor of Liver Research. He has published over 180 manuscripts and hold 8 US patents.
Research Interests
Papers共 378 篇Author StatisticsCo-AuthorSimilar Experts
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Kun-Chen Lin, Kuan-Hung Chen, Pei-Lin Shao,Han-Tan Chai,Pei-Hsun Sung,John Y Chiang, Sheung-Fat Ko,Hon-Kan Yip
Current molecular pharmacology (2024)
World journal of stem cellsno. 6 (2024): 690-707
crossref(2024)
Cellular and molecular gastroenterology and hepatologyno. 1 (2024): 71-87
Journal of integrative and complementary medicine (2024)
Stem cells translational medicineno. 8 (2024): 724-737
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGYno. 5 (2024): 719-735
Cellular and Molecular Gastroenterology and Hepatologyno. 5 (2024): 719-735
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Pharmacological reviews (2024)
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Author Statistics
#Papers: 369
#Citation: 17069
H-Index: 64
G-Index: 124
Sociability: 6
Diversity: 4
Activity: 146
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