基本信息
浏览量:2
职业迁徙
个人简介
The Kuwada lab used a multi-organism approach to investigate genes that are essential for the function of neural circuits in the brain that regulate behavior and how these genes cause human diseases when they are defective. Zebrafish and Drosophila are studied since they are experimentally accessible at all stages of development allowing for analysis in living embryos with electrophysiology and sophisticated imaging based strategies to discern signaling within neural circuits. Importantly zebrafish and Drosophila genes can be studied with powerful methods for the generation of mutant and transgenic animals. Projects included the analysis of several novel genes that regulate voltage-dependent Ca2+ channels in muscles and neurons and thus their excitability. How these genes regulate channels is being analyzed by genetic strategies for manipulating the activity of specific neurons. We found that one of these genes is responsible for a human muscle disease and by inserting the mutant human gene into zebrafish, we discovered how the mutated gene leads to the congenital disease. More recent studies of these genes in zebrafish and Drosophila suggest that they regulate critical signaling at synapses, which are responsible for communication between neurons and neural circuit function.
研究兴趣
论文共 63 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Jeremy W. Linsley, Nadia Perez,I-Uen Hsu, Yuyang Yang, Naveen Jasti,Matthew Waalkes,Eric J. Horstick,John Y. Kuwada
biorxiv(2022)
I-Uen Hsu,Jeremy W Linsley,Xiaoli Zhang,Jade E Varineau,Drew A Berkhoudt, Lilly E Reid, Miranda C Lum, Allison M Orzel,Ari Leflein,Haoxing Xu,Catherine A Collins,Richard I Hume,
NATURE COMMUNICATIONSno. 1 (2018): 2389-2389
user-5fe1a78c4c775e6ec07359f9(2017)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn