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The role of cytokines in regulation of the generation of lymphohemopoietic cells and in inflammatory and neoplastic disease. My particular interest is in interleukin-3. My laboratory was one of the first to purify IL-3 and document its broad range of activities on hemopoietic cells, its importance in mast cell pathophysiology and its role in leukemogenesis. Current research is focussed on signal transduction mechanisms and their perturbation in disease, with an emphasis on two novel proteins we discovered, M-Ras and the Ras Pathway Modulator, RPM. My laboratory has also developed a novel approach to generating monoclonal antibodies and is using it to develop novel therapeutic agents and new tools for research into intracellular processes and gene therapy.
The role of cytokines in regulation of the generation of lymphohemopoietic cells and in inflammatory and neoplastic disease. My particular interest is in interleukin-3. My laboratory was one of the first to purify IL-3 and document its broad range of activities on hemopoietic cells, its importance in mast cell pathophysiology and its role in leukemogenesis. Current research is focussed on signal transduction mechanisms and their perturbation in disease, with an emphasis on two novel proteins we discovered, M-Ras and the Ras Pathway Modulator, RPM. My laboratory has also developed a novel approach to generating monoclonal antibodies and is using it to develop novel therapeutic agents and new tools for research into intracellular processes and gene therapy.
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论文共 83 篇作者统计合作学者相似作者
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Annette Ehrhardt,Bin Wang,Andrew C Yung,Yanni Wang,Piotr Kozlowski,Cornelis van Breemen,John W Schrader
PloS oneno. 10 (2015): e0141493-e0141493
semanticscholar(2013)
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