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个人简介
Research Area: Cell and Molecular Biology
Research Description:
Our main goal is to understand epithelial chloride transport at the molecular level. Most of our effort focuses on CFTR (cystic fibrosis transmembrane conductance regulator), a low-conductance channel which mediates cAMP-stimulated chloride and bicarbonate secretion and is defective in the disease cystic fibrosis. We use site-directed mutagenesis, electrophysiological and imaging methods to study the structure and function of CFTR in heterologous expression systems, cell lines, and primary epithelial cell cultures. A recent emphasis has been the development of F508del-CFTR correctors for the treatment of CF. Other projects investigate the role of CFTR in mucus production and in chronic obstructive pulmonary disease.
Research Description:
Our main goal is to understand epithelial chloride transport at the molecular level. Most of our effort focuses on CFTR (cystic fibrosis transmembrane conductance regulator), a low-conductance channel which mediates cAMP-stimulated chloride and bicarbonate secretion and is defective in the disease cystic fibrosis. We use site-directed mutagenesis, electrophysiological and imaging methods to study the structure and function of CFTR in heterologous expression systems, cell lines, and primary epithelial cell cultures. A recent emphasis has been the development of F508del-CFTR correctors for the treatment of CF. Other projects investigate the role of CFTR in mucus production and in chronic obstructive pulmonary disease.
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论文共 188 篇作者统计合作学者相似作者
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESno. 3 (2024): 1739
Alicia Reyes Valenzuela, Mark Turner,Nathan Markarian,Christophe Lachance-Brais,John W. Hanrahan,Hojatollah Vali, Silvia Vidal,Luc Mongeau
biorxiv(2024)
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGYno. 3 (2023): 281-294
BIOPHYSICAL JOURNALno. 3 (2023): 173A-174A
Martin Ondra, Lukas Lenart,Amanda Centorame,Daciana C Dumut, Alexander He,Syeda Sadaf Zehra Zaidi,John W Hanrahan,Juan Bautista De Sanctis,Danuta Radzioch,Marian Hajduch
Life science allianceno. 1 (2023): e202302045-e202302045
Journal of Cell Science (2022)
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