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个人简介
Professor Tower's research focuses on the molecular genetics of aging in Drosophila melanogaster. He is taking several approaches to his research on aging, the first of which is studying the regulation of gene expression as a function of age, in particular, the heat shock protein genes hsp70 and hsp22, and anti-microbial peptide genes involved in the innate immune response. Increased expression of these genes was found to be a predictive biomarker of aging. The second approach is to identify genes that directly regulate life span. His current emphasis is to test candidate genes involved in regulating oxidative stress responses and nuclear-mitochondrial signaling. He is particularly interested in how the post-mitotic muscle, nerve and liver cells of the adult maintain function during aging, and how stem cells populations are maintained in the ovary. These studies have identified p53 and sexual differentiation as key contributors to aging. Professor Tower is investigating how sex-specific hormones, including steroid hormones and male Sex Peptide hormone can promote sexual differentiation and reproduction at a cost for animal health and life span.
研究兴趣
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FRONTIERS IN AGING (2024): 1376060-1376060
FRONTIERS IN AGING (2023): 1292040-1292040
Gary N Landis,Hans S Bell,Oscar Peng, Brett Bognar, Andy Tong, Tomás D Manea,Hanmei Bao,Xianlin Han,John Tower
PloS oneno. 12 (2023): e0292820-e0292820
Gary N. Landis,Hans S. Bell,Oscar Peng, Brett Bognar, Andy Tong, Tomas D. Manea,Hanmei Bao,Xianlin Han,John Tower
PLOS ONEno. 12 (2023)
Frontiers in aging (2022): 924957
semanticscholar(2022)
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Gary N Landis,Tyler A U Hilsabeck,Hans S Bell,Tal Ronnen-Oron,Lu Wang, Devon V Doherty,Felicia I Tejawinata, Katherine Erickson,William Vu,Daniel E L Promislow,Pankaj Kapahi,John Tower
Gary N Landis, Devon V Doherty,Chia-An Yen,Lu Wang,Yang Fan,Ina Wang, Jonah Vroegop,Tianyi Wang,Jimmy Wu,Palak Patel, Shinwoo Lee, Mina Abdelmesieh,
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