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Our lab investigates the genetics and mechanisms of reproduction, meiosis, and genome maintenance. A major focus concerns checkpoint mechanisms that detect errors in germ cell development so as to protect against chromosome aberrations and birth defects in offspring. We also study how defects in DNA replication lead to genetic aberrations, developmental abnormalities, and cancer. Finally, we have undertaken a project to identify human infertility alleles in human populations using CRISPR-mediated modeling in mice.
Our lab investigates the genetics and mechanisms of reproduction, meiosis, and genome maintenance. A major focus concerns checkpoint mechanisms that detect errors in germ cell development so as to protect against chromosome aberrations and birth defects in offspring. We also study how defects in DNA replication lead to genetic aberrations, developmental abnormalities, and cancer. Finally, we have undertaken a project to identify human infertility alleles in human populations using CRISPR-mediated modeling in mice.
研究兴趣
论文共 262 篇作者统计合作学者相似作者
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bioRxiv : the preprint server for biology (2024)
Trends in genetics : TIGno. 4 (2024): 326-336
bioRxiv : the preprint server for biology (2024)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
CANCER RESEARCHno. 7 (2023)
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Yasuhiro Fujiwara, Kouhei Saito,Fengyun Sun, Sabrina Petri, Erina Inoue,John Schimenti,Yuki Okada,Mary Ann Handel
Rebecca M Williams,Jordana C Bloom,Cara M Robertus, Andrew K Recknagel,David Putnam,John C Schimenti,Warren R Zipfel
Journal of microscopyno. 3 (2023): 237-247
Cancer Researchno. 7_Supplement (2023): 175-175
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Yasuhiro Fujiwara, Kouhei Saito,Fengyun Sun,Sabrina Petri, Erina Inoue,John Schimenti,Yuki Okada,Mary Ann Handel
Reproduction (Cambridge, England)no. 6 (2023): 437-450
biorxiv(2023)
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