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The Orthopaedic Hospital Research Center (OHRC) was formed in 2007 under the direction of John S. Adams, M.D. The aim of the OHRC is to create an interdisciplinary (Departments of Orthopaedic Surgery, Molecular Cell and Developmental Biology, Medicine, Broad Stem Cell Institute, etc.), interschool (medical, dental, engineering, etc.) research effort targeted at understanding and treating the most vexing issues in human musculoskeletal disease. Within this framework, the Adams laboratory is dedicated to an understanding of the molecular motive action of vitamin D as both a hormonal regulator of bone and mineral homeostasis as well as a locally-functioning monokine modulating the innate and adaptive immune response in infectious and autoimmune diseases affecting humans. Specifically, we investigate naturally-occurring experiments of nature in human and subhuman primates and transgenic mouse models of those experiments to better understand the means by which vitamin D and other steroid hormones (e.g. estrogen) control gene expression. On a more clinical-translational level we study the consequences of vitamin D insufficiency on the state of immunoreactivity and bone balance in the human host.
The Orthopaedic Hospital Research Center (OHRC) was formed in 2007 under the direction of John S. Adams, M.D. The aim of the OHRC is to create an interdisciplinary (Departments of Orthopaedic Surgery, Molecular Cell and Developmental Biology, Medicine, Broad Stem Cell Institute, etc.), interschool (medical, dental, engineering, etc.) research effort targeted at understanding and treating the most vexing issues in human musculoskeletal disease. Within this framework, the Adams laboratory is dedicated to an understanding of the molecular motive action of vitamin D as both a hormonal regulator of bone and mineral homeostasis as well as a locally-functioning monokine modulating the innate and adaptive immune response in infectious and autoimmune diseases affecting humans. Specifically, we investigate naturally-occurring experiments of nature in human and subhuman primates and transgenic mouse models of those experiments to better understand the means by which vitamin D and other steroid hormones (e.g. estrogen) control gene expression. On a more clinical-translational level we study the consequences of vitamin D insufficiency on the state of immunoreactivity and bone balance in the human host.
Research Interests
Papers共 828 篇Author StatisticsCo-AuthorSimilar Experts
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Pradeep Annamalai Subramani,Phornpimon Tipthara, Surendra Kumar Kolli,Justin Nicholas,Samantha J Barnes,Madison M Ogbondah, Kevin C Kobylinski,Joel Tarning,John H Adams
Antimicrobial agents and chemotherapyno. 8 (2024): e0127223-e0127223
Feldman and Pike' s Vitamin Dpp.155-187, (2024)
Janet Conway, Ronald E Delanois,Michael A Mont,Alexandra Stavrakis, Edward McPherson, Edward Stolarski,Stephen Incavo,Daniel Oakes, Ralph Salvagno,John S Adams, Adriane Kisch-Hancock,Edgar Tenorio,
Antimicrobial agents and chemotherapyno. 8 (2024): e0065524-e0065524
John J. Mitchell,Michal Inbar-Feigenberg,Kim Angel,Pranesh Chakraborty,Monica Lamoureux,John Adams,Beth K. Potter, Sylvia Stockler-Ipsirolgu,Alison H. Howie, Alex Pace,Nancy J. Butcher,Cheryl Greenberg,
MOLECULAR GENETICS AND METABOLISMno. 2 (2024)
Gabriela M. Fernandes, Guilherme H. Rodrigues-Mattos,Leticia M. Torres, Karla S. Guedes,Francis B. Ntumngia,John H. Adams,Cristiana F. A. Brito,Flora S. Kano,Tais N. de Sousa,Luzia H. Carvalho
Infection, genetics and evolution journal of molecular epidemiology and evolutionary genetics in infectious diseases (2024): 105628-105628
Research square (2024)
Scientific Reportsno. 1 (2024)
SOUTHWESTERN HISTORICAL QUARTERLYno. 3 (2024): 269-286
PLOS NEGLECTED TROPICAL DISEASESno. 1 (2024): e0011907-e0011907
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Author Statistics
#Papers: 813
#Citation: 38741
H-Index: 87
G-Index: 178
Sociability: 8
Diversity: 4
Activity: 87
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