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Dr. Cooke’s research program is focused on vascular regeneration, vascular cell identity and cell fate. The program is funded by grants from the National Institutes of Health, the American Heart Association, Cancer Prevention Research Institute, and industry.
The Cooke group aims to understand the mechanisms underlying epigenetic plasticity that are required for functional adaptation to cellular challenges. Innate immune signaling causes global changes in the expression and activity of epigenetic modifiers with metabolic coupling that favors an open chromatin configuration. The translational output of this work is vascular regeneration via therapeutic transdifferentiation using small molecules or mRNA. In his 25 years of translational vascular biology, Dr. Cooke first described and characterized the anti-atherogenic effects of endothelium-derived nitric oxide; the anti-angiogenic effect of the NO synthase inhibitor ADMA; the angiogenic pathway mediated by endothelial nicotinic acetylcholine receptors; the role for this pathway in states of pathological angiogenesis; and developed an antagonist of the pathway that was tested in clinical trials. His clinical research group has explored the use of angiogenic agents and adult stem cells in the treatment of peripheral arterial disease. More recently, his group has generated and characterized vascular cells diferentiated from iPSCs of patients with Progeria, to understand the role of telomere erosion in this condition of accelerated aging and vascular death. His group's applicaiton of mRNA encoding human telomerase to reverse aging in this condition, and other age-related diseases, is promising.
The Cooke group aims to understand the mechanisms underlying epigenetic plasticity that are required for functional adaptation to cellular challenges. Innate immune signaling causes global changes in the expression and activity of epigenetic modifiers with metabolic coupling that favors an open chromatin configuration. The translational output of this work is vascular regeneration via therapeutic transdifferentiation using small molecules or mRNA. In his 25 years of translational vascular biology, Dr. Cooke first described and characterized the anti-atherogenic effects of endothelium-derived nitric oxide; the anti-angiogenic effect of the NO synthase inhibitor ADMA; the angiogenic pathway mediated by endothelial nicotinic acetylcholine receptors; the role for this pathway in states of pathological angiogenesis; and developed an antagonist of the pathway that was tested in clinical trials. His clinical research group has explored the use of angiogenic agents and adult stem cells in the treatment of peripheral arterial disease. More recently, his group has generated and characterized vascular cells diferentiated from iPSCs of patients with Progeria, to understand the role of telomere erosion in this condition of accelerated aging and vascular death. His group's applicaiton of mRNA encoding human telomerase to reverse aging in this condition, and other age-related diseases, is promising.
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Khanh M. Chau,Abishai Dominic,Eleanor L. Davis,Sivareddy Kotla,Estefani Turcios Berrios, Arsany Fahim, Ashwin Arunesh,Shengyu Li, Dongyu Zhao,Kaifu Chen,Alan R. Davis,Minh T. H. Nguyen,
FRONTIERS IN CARDIOVASCULAR MEDICINE (2024): 1213428-1213428
Naseeb Kaur Malhi,Yingjun Luo,Xiaofang Tang, Rahuljeet Singh Chadha,Alonso Tapia,Xuejing Liu, Muxi Chen,Dongqiang Yuan,Meirigeng Qi, Lu Wei,John P Cooke,Rama Natarajan,
bioRxiv : the preprint server for biology (2024)
Journal of the American College of Cardiologyno. 13 (2024): 2407
Anna Laura Nelson, Chiara Mancino,Xueqin Gao,Joshua A. Choe,Laura Chubb,Katherine Williams, Molly Czachor,Ralph Marcucio,Francesca Taraballi,John P. Cooke,Johnny Huard,Chelsea Bahney,
Bioactive Materials (2024): 273-286
Priyanka Banerjee,Khanh Chau,Sivareddy Kotla,Eleanor L Davis,Estefani Berrios Turcios, Shengyu Li,Zhang Pengzhi, Guangyu Wang, Gopi Krishna Kolluru,Abhishek Jain,John P Cooke,Junichi Abe,
Priyanka Banerjee,Khanh Chau,Sivareddy Kotla,Eleanor L. Davis,Estefani Berrios Turcios, Shengyu Li,Zhang Pengzhi,Guangyu Wang, Gopi Krishna Kolluru,Abhishek Jain,John P. Cooke,Junichi Abe,
Nature Communicationsno. 1 (2023)
Journal of the American College of Cardiologyno. 8 (2023): 1469-1469
Jun-Ichi Abe, Masaki Imanishi,Shengyu Li,Aijun Zhang,Kyung Ae Ko, Venkata S K Samanthapudi, Ling-Ling Lee, Angelica Paniagua Bojorges, Young Jin Gi, Brian P Hobbs,Anita Deswal,Joerg Herrmann,
Circulation researchno. 1 (2023): 25-44
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