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Cells of higher vertebrates have evolved mechanisms enabling them to display on their surfaces a sampling of their intracellular contents, in the form of peptides bound to major histocompatibility complex MHC class I molecules. Such complexes are required not only for the recognition and destruction of cells harboring intracellular pathogens, or cells containing altered forms of self proteins, such as oncogenes, but also for the positive and negative selection of T cells during their development in the thymus. It is therefore important to determine how these peptide-MHC complexes are generated. Moreover, recent data suggest that not all peptides of a given antigen which can bind to a particular MHC class I molecule are in fact produced under normal circumstances, and that polymorphism in antigen processing may alter the repertoire of peptides presented to T cells in different individuals. Thus, it is important to determine whether and to what extent the specificity of, and potential polymorphism in, their generation affects the repertoire of peptides that are presented to T cells.
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Cell biochemistry and biophysicsno. 1-2 (2011): 119-126
Journal of Immunologyno. 7.0 (2006): 4075-4082
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