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Dr. Lemasters has a long-standing interest in the role of mitochondrial metabolism in hepatopathobiology, especially in relation to ischemia-reperfusion (IR) injury, ethanol/drug-induced hepatic injury, liver preservation for transplantation, cancer, and mitochondrial autophagy (mitophagy). His in vitro and in vivo studies of living cells and tissues have shown that mitochondrial calcium uptake, iron translocation from lysosomes to mitochondria and oxidative stress promote the mitochondrial permeability transition (MPT). The MPT initially induces lysosomal degradation of mitochondria by autophagy, a selective process called mitophagy. However, after ischemia/reperfusion, oxidative stress, liver storage and transplantation, acetaminophen hepatotoxicity and other stresses to the liver, excess MPT onset induces both necrotic cell death from ATP depletion and apoptosis due to cytochrome c release after mitochondrial swelling. Dr. Lemasters has also shown similar events occurring in cardiac myocytes subjected to ischemia/reperfusion.
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JOURNAL OF NATURAL PRODUCTSno. 7 (2022): 1779-1788
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