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Genetic decoding is dynamic. It can be altered in an mRNA- or site-specific manner and in a remarkable variety of ways. The meaning of individual codons can be redefined in response to signals in mRNA. A proportion of translating ribosomes can be diverted at a specific site to a different reading frame. They can also be directed to bypass a block of nucleotides - at least up to 50 - or even to resume on a different mRNA. We are studying these "recoding" phenomena to determine where they occur, understand their functional significance, elucidate the mechanisms involved, and where desirable plot intervention strategies.
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Simon Fromm,Kate Marie O'Connor, Michael Purdy,Pramod R. Bhatt, Gary Longharn,John F. Atkins,Ahmad Jomaa,Simone Mattei
Acta Crystallographicano. a1 (2023): A132-A132
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Nature communicationsno. 1 (2023): 1095
Ivan V. Antonov,Sinead O'Loughlin, Alessandro N. Gorohovski,Patrick B. F. O'Connor,Pavel V. Baranov,John F. Atkins
RNA BIOLOGYno. 1 (2023): 926-942
NATUREno. 7945 (2023): 631-632
Sofya A Gaydukova, Mikhail A Moldovan,Adriana Vallesi,Stephen M Heaphy,John F Atkins,Mikhail S Gelfand,Pavel V Baranov
Proceedings of the National Academy of Sciences of the United States of Americano. 22 (2023)
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Sofya Gaydukova, Mikhail Moldovan,Adriana Vallesi, Stephen M. Heaphy,John F Atkins,Mikhail S. Gelfand,Pavel V. Baranov
bioRxiv (Cold Spring Harbor Laboratory) (2022)
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