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The antibody and T cell repertoires are somatically generated by combinatorial joining of variable region gene segments mediated by special recombinases. This generates a broad and sometime autoreactive pre-immune antibody repertoire, e.g. the innate natural antibody repertoire. This immature repertoire is refined and diversified by somatic hypermutation and selection to fashion an adaptive immune response/system. Refinement also involves changes in the class or subclass of antibodies used, e.g. IgG, IgA, etc. Four extrinsic factors; diet, maternal regulatory factors, gut flora and pathogens, impact the development of the adaptive immune system during a narrow window of neonatal life. Understanding how these factors promote the transition to adaptive immunity is important in human and animal health. Our studies utilize the isolator piglet model in which all four of theses extrinsic factors can be controlled by the experimenter. Of particular interest is the role played by colonizing gut flora, including probiotics, on repertoire development. Colonizing bacteria and some viruses are recognized by innate immune receptors, e.g. TLRs, and are required for development of adaptive immunity. In particular we continue to be interested in the role of the ileal Peyers patches which we have proposed to act as “first responder” mucosal immune tissue. As emeritus professor I will continue to advise and collaborate with other laboratories to pursue these studies. I will also continue to advise genetic engineering projects for developing B cell knockout pigs to make human antibodies and to prepare chimeric-camelid antibodies for species in which purified immunoglobulins can only produced in vitro.
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论文共 127 篇作者统计合作学者相似作者
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Katerina Stepanova,Miroslav Toman,Jana Sinkorova,Simon Sinkora, Sarka Pfeiferova, Helena Kupcova Skalnikova, Salim Abuhajiar,Romana Moutelikova, Jiri Salat, Hana Stepanova, Katerina Nechvatalova,Lenka Leva,
FRONTIERS IN IMMUNOLOGY (2024): 1292381-1292381
Frontiers in immunology (2020): 399-399
Frontiers research topics (2020)
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Annual review of animal biosciencesno. 1 (2017): 255-279
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