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The laboratory investigates the mechanism and biological function of reversible protein modifications involved in modulating signal transduction, chromatin dynamics and gene activation. Histones are one of the best examples of protein function regulated by modification, and are the target of an array of modifications including acetylation, phosphorylation and methylation. The dynamic and specific nature of these modifications has led to the proposal that there is a “Histone Code”, which when decoded would allow us to understand, for instance, what is required to maintain “silenced” or “active” chromatin. In general, histone acetylation (catalyzed by histone acetyltransferases) correlates with gene transcription, while hypo-acetylation (catalyzed by protein deacetylases) correlates with repression. To begin to understand this signaling code, we must first understand the mechanisms and regulation of the enzymes responsible for these modifications. A large component of our work is to understand the major enzyme families that catalyze these reactions.
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Cancer Researchno. 11_Supplement (2023): B051-B051
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Spencer A Haws,Yang Liu,Cara L Green,Reji Babygirija,Eric A Armstrong, Anusha T Mehendale,Dudley W Lamming,John M Denu
bioRxiv : the preprint server for biology (2023)
Gonzalo Fernandez-Fuente,Katherine Overmyer,Alexis Lawton,Ildiko Kasza, Patricia Gallego-Muoz,Joshua Coon,John Denu,Caroline Alexander,Luigi Puglielli
Journal of Biological Chemistryno. 3 (2023): 103955-S512
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Spencer A Haws, Lillian J Miller, Diego Rojas La Luz,Vyacheslav I Kuznetsov,Raymond C Trievel,Gheorghe Craciun,John M Denu
Communications Biologyno. 1 (2023): 1-17
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Narayanan Puthillathu Vasudevan,Dharmendra K Soni,John R Moffett,Jishnu K S Krishnan,Abhilash P Appu,Sarani Ghoshal,Peethambaran Arun,John M Denu,Thomas P Flagg,Roopa Biswas,Aryan M Namboodiri
Tanaya A. Purohit,Joseph Gawdzik,Bing Yang,Eric A. Armstrong,Peter W. Lewis,John M. Denu,David F. Jarrard
CANCER RESEARCHno. 11 (2023): A060-A060
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