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Our lab is interested in how intracellular pathogens parasitize host cells and how the host, in turn, recognizes these pathogens and defends against them. We use the bacterium Listeria monocytogenes, a Gram positive foodborne pathogen, as a model organism to address these questions. L. monocytogenes is capable of infecting a wide variety of cell types, including professional phagocytes such as macrophages and dendritic cells. Survival from infection with L. monocytogenes results in the development of robust and long term protective cell mediated immunity. To understand the complex game of tug and war between the bacteria and the host, we utilize genetics, both in the pathogen and in the host, to determine the factors necessary to promote disease (pathogen) and immunity (host).
Research Interests
Papers共 83 篇Author StatisticsCo-AuthorSimilar Experts
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Morgan A. Giese,Gayathri Ramakrishnan, Laura H. Steenberge, Jerome X. Dovan,John-Demian Sauer,Anna Huttenlocher
biorxiv(2024)
iScienceno. 4 (2024): 109532-109532
bioRxiv the preprint server for biology (2024)
Toxicon (2024): 107507
Korbin H J West, Stella V Ma, Daniel A Pensinger,Trisha Tucholski,Timothy N Tiambeng,Emma L Eisenbraun,Avishag Yehuda,Zvi Hayouka,Ying Ge,John-Demian Sauer,Helen E Blackwell
Biochemistryno. 19 (2023): 2878-2892
Journal of bacteriology (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
INFECTION AND IMMUNITYno. 10 (2023)
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