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My lab investigates how eukaryotic cells sense, respond to and resolve cellular stress through the mechanisms of protein quality control that ensure proteome fidelity. Cellular stress is a hallmark of cancers (e.g. multiple myeloma, prostrate, breast) and many other diseases and the integrated processes overseeing protein folding and degradation are essential for transformed cells to withstand the atypical and adverse conditions brought about by disease. We have a long-standing interest in the protein quality control mechanisms at work in the endoplasmic reticulum (ER) and, specifically, the molecular machinery and substrates of ER-associated degradation (ERAD); a multifaceted process responsible for clearing misfolded and surplus proteins from the ER through the ubiquitin-proteasome system.
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Blood cancer journalno. 1 (2023): 12-12
Nature reviews. Molecular cell biologyno. 11 (2023): 777-796
CHEMICAL SCIENCEno. 45 (2023): 12973-12983
Catarina J Gaspar, Lígia C Vieira, Cristiana C Santos,John C Christianson,David Jakubec,Kvido Strisovsky,Colin Adrain,Pedro M Domingos
Emma J Fenech,Federica Lari, Philip D Charles,Roman Fischer, Marie Laétitia-Thézénas, Katrin Bagola,Adrienne W Paton, James C Paton,Mads Gyrd-Hansen, Benedikt M Kessler,John C Christianson
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