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Rotaviruses are a large genetically diverse and rapidly evolving population of icosahedral viruses with genomes consisting of segmented double-stranded RNA. These viruses are major causes of severe diarrheal disease in the young of many animal species, including humans, pets, livestock, and birds. In infants and young children, rotavirus infections account for approximately 200,000 deaths each year, most occurring in developing countries of Africa and Asia. Several developed countries, including the US, have introduced rotavirus vaccines into their childhood immunization programs; these vaccines that have been remarkably effective in preventing severe diarrheal disease. However, in developing countries, these same vaccines have been significantly less effective for reasons that remain unclear. Our laboratory studies rotavirus molecular biology and pathogenesis, in hopes of providing fundamental knowledge useful for advancing new ways of treating and preventing rotavirus disease.
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论文共 296 篇作者统计合作学者相似作者
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Virusesno. 3 (2024): 411
Methods in molecular biology (Clifton, N.J.) (2024): 249-263
VIRUSES-BASELno. 3 (2024)
MICROBIOLOGY RESOURCE ANNOUNCEMENTSno. 11 (2023): e0060323-e0060323
JOURNAL OF GENERAL VIROLOGYno. 10 (2023)
Jiajie Wei,Scott Radcliffe, Amanda Pirrone,Meiqing Lu,Yuan Li, Jason Cassaday,William Newhard,Gwendolyn J. Heidecker, William A. Rose Ii,Xi He, Daniel Freed,Michael Citron,
VIRUSES-BASELno. 10 (2023): 2034-2034
Charlotte Nyblade,Peng Zhou,Maggie Frazier,Annie Frazier,Casey Hensley,Ariana Fantasia-Davis, Shabihah Shahrudin, Miranda Hoffer,Chantal Ama Agbemabiese, Lauren LaRue,Mario Barro,John T. Patton,
Virusesno. 1864 (2023): 1864-1864
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