John A. Zaia
Director
Center of Gene Therapy
City of Hope;INDuarte Consulting, LLC;City of Hope Alpha Stem Cell Clinic, City of Hope;Institutional Official for Research, City of Hope;City of Hope General Clinical Research Center Satellite, School of Medicine, University of Southern California;Department of Pediatrics, City of Hope
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个人简介
Cytomegalovirus (CMV)-specific cellular immune responses in hematopoietic cell transplant (HCT) recipients at City of Hope. In collaboration with the Department of Hematology & Hematopoietic Cell Transplantation, our laboratory has been observing patients undergoing HCT who are at risk for CMV infection and asking the question of what elements of immunity are most important for protection from CMV infection in the recipient. A nontherapeutic clinical trial followed patients with such assays as: a) tetramer binding assay (TBA) to locate T cell recognizing the HLA A2 and B7 presenting CMV peptides; this is done in collaboration with our colleagues Simon Lacey and Don Diamond, b) intra-cellular cytokine (ICC) to locate CD4 and CD8 cells that are activated by CMV peptides and releasing interferon-gamma, c) Q-PCR to detect CMV DNA in plasma, and d) presence of PD-1 expression in T cells, and effect of KIR genotyping on outcome (this was done in collaboration with our colleagues D. Senitzer and J. Sun.
研究兴趣
论文共 211 篇作者统计合作学者相似作者
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Hildegund C.J. Ertl,John Zaia,Steven A. Rosenberg,Carl H. June,Gianpietro Dotti,Jeffrey Kahn,Laurence J.N. Cooper, Jacqueline Corrigan-Curay,Scott E. Strome
crossref(2023)
crossref(2023)
Flavia Chiuppesi, Sandra Ortega-Francisco,Miguel-Angel Gutierrez, Jing Li,Minh Ly,Katelyn Faircloth, Jada Mack-Onyeike,Corinna La Rosa,Sandra Thomas,Qiao Zhou,Jennifer Drake,Cynthia Slape,
Vaccinesno. 1492 (2023): 1492-1492
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Angelo A. Cardoso,Rodica Stan,Monica Torres-Coronado,Jay Lalezari, Ronald Mitsuyasu, Anthony Mills,Agnes Gardner,Diana L. Browning,Li Xiu-Li, Jonathan Chupka,Michael C. Holmes, Marina Falaleeva,
MOLECULAR THERAPYno. 4 (2023): 191-191
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Evan A Elko,Georgia A Nelson,Heather L Mead,Erin J Kelley, Sophia T Carvalho,Nathan G Sarbo, Caroline E Harms,Virginia Le Verche,Angelo A Cardoso,Jennifer L Ely,Annalee S Boyle,Alejandra Piña,
Flavia Chiuppesi,John A Zaia,Paul H Frankel,Rodica Stan,Jennifer Drake, Brenda Williams,Anne Marie Acosta,Karyn Francis,Randy A Taplitz, Janet K Dickter,Sanjeet Dadwal,Alfredo G Puing,
Flavia Chiuppesi,John A. Zaia,Katelyn Faircloth,Daisy Johnson, Minh Ly,Veronica Karpinski,Corinna La Rosa,Jennifer Drake, Joan Marcia, Ann Marie Acosta, Shannon Dempsey,Randy A. Taplitz,
medRxiv : the preprint server for health sciences (2022)
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