Research Interest Characterizing the pharmacology of drugs to prevent chemotherapy-induced acute and delayed emesis using animal models with proven translational value; connection with the pharmaceutical industry to make discoveries a reality. Understanding mechanisms of gastric dysrhythmia following anticancer treatment; interstitial cells of Cajal (ICC); value of prokinetic drugs. Understanding mechanisms of cancer cachexia; development of meaningful animal models. Role of forebrain to brainstem mechanisms controlling feeding and homeostasis and behaviors indicative of nausea; emetic liability mechanisms. Mechanisms of taste and smell alterations during chemotherapy. Publications Rudd, J.A., Ngan, M.P., Lu, Z., Higgins, G., Giuliano, C., Lovati, E., and Pietra, C. (2016). Profile of antiemetic activity of netupitant alone or in combination with palonosetron and dexamethasone in ferrets and Suncus murinus (house musk shrew). Frontiers in Pharmacology, 7, 236. DOI: 10.3389/fphar.2016.00263. Guimaraes, D.D., Andrews, P.L.R., Rudd, J.A., Braga, V.A., and Nalivaiko, E. (2016). Ondansetron and promethazine have differential effects on hypothermic responses to lithium chloride administration and to provocative motion in rats. Temperature, 2, 543-553. Rudd, J.A., Nalivaiko E., Matsuki, N., Wan C. and Andrews, P.L.R. (2015). The involvement of TRPV1 in emesis and anti-emesis. Temperature, 2, 258-276. Sin T.K., Tam B.T., Yung B.Y., Yip S.P., Chan L.W., Wong C.S., Ying M., Rudd J.A., and Siu P.M. (2015). Resveratrol protects against doxorubicin-induced cardiotoxicity in aged hearts through the SIRT1-USP7 axis. Journal of Physiology, 593, 1887-1899. Lu, Z., Percie du Sert, N, Chan, S.W., Yeung, C.K., Lin, G., Yew, D.T.W., Andrews, P.L.R., and Rudd, J.A. (2015). Differential hypoglycaemic, anorectic, autonomic and emetic effects of the glucagon-like peptide receptor agonist, exendin-4, in the conscious telemetered ferret. Journal of Translational Medicine, 12, 1-13. Nalivaiko, E., Rudd, J.A., and So, R. (2014). Motion sickness, nausea and thermoregulation: the "toxic" hypothesis. Temperature, 1, 164-171. Ullah, I., Subhan, F., Rudd, J.A., Rauf, K., Alam, J., Shahid, M., and Sewll, R.D.E. (2014). Attenuation of cisplatin-induced emetogenesis by standardized Bacopa monnieri extracts in the pigeon: behavioral and neurochemical correlations. Planta Medica., 80, 1569-1579. Chan, S.W., Lu, Z., Lin, G., Yew, D.T.W., Yeung, C.K., and Rudd, J.A. The differential antiemetic properties of GLP-1 receptor antagonist, exendin (9-39) in Suncus murinus (house musk shrew). Neuropharmacology, 83, 71-78. Ngampramuan, S., Cerri, M., Vecchio, F.D., Corrigan, J.J., Kamphee, A., Dragic, A.S., Rudd, J.A., Romanovsky, A.A., Nalivaiko, E. (2014). Thermoregulatory correlates of nausea in rats and musk shrews. Oncotarget, 5, 1565-1575. Johnston, K.D., Lu, Z., & Rudd, J.A. (2014). Looking beyond 5-HT3 receptors: a review of the wider role of serotonin in the pharmacology of nausea and vomiting. Eur. J. Pharmacol., 722, 13-25.