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个人简介
Johannes Kornhuber (born September 11, 1959) is a German psychiatrist and psychotherapist.
Kornhuber worked in the Department of Psychiatry at the University of Würzburg, Germany, as Postdoctoral Fellow, Resident and Supervising Physician. In 1996 he obtained an appointment to a full professorship in the Department of Psychiatry at the University of Göttingen, Germany, where he was Chairman of the Gerontopsychiatric Section. Since 2000, Kornhuber has been a full professor and chairman in the Department of Psychiatry at the University of Erlangen-Nuremberg, Germany.
His research interests include the pathophysiology of Alzheimer’s disease, the early diagnosis and treatment of dementia syndromes, the pathophysiology of alcohol addiction and the pathophysiology of major depressive disorder. He has authored or co-authored more than 400 Journal articles. Kornhuber described novel molecular mechanisms of approved psychotropic drugs, namely that memantine, amantadine, budipine and orphenadrine act as low-affinity NMDA-receptor antagonists.
The data obtained with memantine formed an important basis for its worldwide approval as an antidementive drug. Kornhuber developed the pharmacokinetic hypothesis explaining the delayed therapeutic effects of antidepressant drugs.Furthermore, he found that antidepressant drugs like amitriptyline and fluoxetine mediate their effects on neurogenesis and behavior by lowering ceramide abundance in the brain.Among his coauthors has been Peter Riederer.
研究兴趣
论文共 592 篇作者统计合作学者相似作者
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Frontiers in aging neuroscience (2023): 1121500
Molecular Psychiatryno. 7 (2023): 2683-2696
Liubov S Kalinichenko,Christiane Mühle,Tianye Jia,Felix Anderheiden,Maria Datz, Anna-Lisa Eberle,Volker Eulenburg,Jonas Granzow,Martin Hofer,Julia Hohenschild,Sabine E Huber, Stefanie Kämpf,
JOURNAL OF ALZHEIMERS DISEASEno. 1 (2023): 265-275
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BRAIN COMMUNICATIONSno. 2 (2023): fcad076-fcad076
Journal of Alzheimer's Diseaseno. 1 (2023): 265-275
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Stefan Mestermann,Peter A Fasching,Matthias W Beckmann,Jennifer Gerlach,Oliver Kratz,Gunther H Moll,Johannes Kornhuber,Anna Eichler, The Imac-Mind-Consortium
Children (Basel, Switzerland)no. 5 (2023): 866-866
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