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个人简介
Dr. Walter’s lab has made the following contributions to our understanding of DNA replication and repair:
identified a replication-coupled proteolysis pathway that limits DNA replication to a single round per cell cycle
discovered how the replicative DNA helicase (CMG) interacts with DNA at the replication fork
elucidated two mechanisms of replication-coupled DNA interstrand cross-link (ICL) repair
showed that the Fanconi anemia pathway promotes incisions during ICL repair
discovered that DNA protein cross-links are repaired by a replication-coupled protease
elucidated the mechanism of replication termination in vertebrates
pioneered the use of frog egg extracts for single molecule studies of DNA replication and repair
identified a replication-coupled proteolysis pathway that limits DNA replication to a single round per cell cycle
discovered how the replicative DNA helicase (CMG) interacts with DNA at the replication fork
elucidated two mechanisms of replication-coupled DNA interstrand cross-link (ICL) repair
showed that the Fanconi anemia pathway promotes incisions during ICL repair
discovered that DNA protein cross-links are repaired by a replication-coupled protease
elucidated the mechanism of replication termination in vertebrates
pioneered the use of frog egg extracts for single molecule studies of DNA replication and repair
研究兴趣
论文共 154 篇作者统计合作学者相似作者
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Nature Communicationsno. 1 (2024): 1-13
Raphael Pavani,Veenu Tripathi,Dali Zong,Elsa Callen, Ajith Pankajam,Andre Nussenzweig,Wei Wu,Kyle Vrtis,Raj Chari,Johannes C. Walter
CANCER RESEARCHno. 1 (2024)
bioRxiv : the preprint server for biology (2024)
Yang Lim,Lukas Tamayo-Orrego, Ernst Schmid,Zygimante Tarnauskaite,Olga V. Kochenova, Rhian Gruar,Sachiko Muramatsu,Luke Lynch, Aitana Verdu Schlie,Paula L. Carroll,Gheorghe Chistol,Martin A. M. Reijns,
SCIENCEno. 6664 (2023): 1301-+
Jan M. Suski,Nalin Ratnayeke,Marcin Braun,Tian Zhang,Vladislav Strmiska,Wojciech Michowski,Geylani Can,Antoine Simoneau, Konrad Snioch, Mikolaj Cup, Caitlin M. Sullivan,Xiaoji Wu,
biorxiv(2022)
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