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Jodi Nunnari’s laboratory is interested in the cellular mechanisms underlying mitochondrial behavior. Mitochondria are double membrane-bounded organelles that perform a myriad of diverse and essential functions in cells, dependent on the collective behavior of the organelle. Their work has addressed the physiological functions and mechanisms of mitochondrial division and fusion, which are critical determinants of overall mitochondrial shape and distribution. They have uncovered contact sites that intimately link mitochondria with the ER and described their roles in mitochondrial positioning and dynamics and mtDNA segregation. They have addressed how mitochondrial membranes are sub-compartmentalized to reveal how the complex internal architecture of the organelle is generated. They are using system-based approaches to address how mitochondrial behavior is physiologically regulated within cells and organisms to shed light onto how mitochondrial dysfunction contributes to human disease.
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论文共 122 篇作者统计合作学者相似作者
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Daniel T. Hughes, Karinder K. Brar,Jordan L. Morris,Kelly Subramanian, Shivaani Krishna,Fei Gao, Lara-Sophie Rieder, Joshua Freeman,Heather L. Smith, Rebekkah Jukes-Jones,Jodi Nunnari,Julien Prudent,
biorxiv(2022)
The EMBO Journalno. 6 (2018)
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