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Bio
Academic Interests
Dr. Jobin is interested in bacteria/host interactions and ensuring innate/immunological responses during health and diseases. The intestine poses an interesting conundrum – it must peacefully cohabit with a sea of commensal bacteria (~100 trillion) and a high load of bacterial products, but swiftly respond to the presence of pathogenic micro-organisms that threaten its integrity. A major clinical consequence of deregulated bacteria/host interaction in the intestine is the development of inflammatory bowel diseases (IBD) and colorectal cancer. Using mice and zebrafish housed in germ-free and gnotobiotic conditions, microbiome techniques (next-generation sequencing, microbial gene mutations, microbial RNA-sequence, etc.), Dr. Jobin studies the differential contribution of bacteria in protecting or exacerbating development of colitis and colorectal cancer. Dr. Jobin has contributed to the understanding of the cellular and molecular mechanism regulating host response to bacterial colonization, and has published numerous papers on innate signaling events taking place in the intestine and how these impact intestinal homeostasis.
Research Interests
Papers共 415 篇Author StatisticsCo-AuthorSimilar Experts
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Amy M Peiper, Joyce Morales Aparicio, Lufuno Phophi, Zhengzheng Hu,Emily W Helm,Matthew Phillips,Caroline G Williams,Saravanan Subramanian, Michael Cross,Neha Iyer,Quyen Nguyen,Rachel Newsome,
bioRxiv : the preprint server for biology (2024)
Meng Yang, Xiaoqi Zheng, Jiajun Fan,Wei Cheng,Tong-Meng Yan,Yushan Lai, Nianping Zhang, Yi Lu, Jiali Qi, Zhengyi Huo, Zihe Xu, Jia Huang,
Amy M Peiper, Joyce Morales, Lufuno Phophi, Zhengzheng Hu,Matthew Phillips,Caroline G Williams,Saravanan Subramanian, Michael Cross,Neha Iyer,Quyen Nguyen,Rachel C Newsome,Christian Jobin,
crossref(2024)
GUT MICROBESno. 1 (2024): 2363012-2363012
Nadia Kabbej,Frederick Ashby, Erika Atencio,Erinn Rosenkrantz, Dominique Day, Khloe Dang,Josee Gauthier,Rachel Newsome, John Sommerville, Taqwa Naas,Raad Gharaibeh,Christian Jobin,
Cancer Researchno. 6_Supplement (2024): 756-756
Michael W. Dougherty, Ryan M. Hoffmann, Yougant Airan,Raad Z. Gharaibeh,Seth B. Herzon,Ye Yang,Christian Jobin
Gastroenterologyno. 5 (2024): S-253
Michael W. Dougherty, Ryan M. Hoffmann, Yougant Airan,Raad Z. Gharaibeh,Seth B. Herzon,Ye Yang,Christian Jobin
Gastroenterologyno. 5 (2024)
SEMINARS IN IMMUNOLOGY (2023): 101756-101756
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