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个人简介
I am a researcher at CICECO - University of Aveiro, as part of the project "BetterBone: Metabolite-activated 3D stem cell differentiation into bone". My main activities are related with the use omics (metabolomics and proteomics) to: i) identify and exploit the most relevant osteoinductive metabolites that will ensure the predominance of osteoblast-like cells; and ii) identify relevant metabolites that can effectively stimulate osteogenic differentiation in 3D cultures, with no co-differentiation into other lineages. I am also working on the application of omics strategies to obtain comprehensive biological understanding of the impact of exposure to chemical stressors and/or specific perturbations and the identification of biomarkers; and ii) food quality assessment. Additionally, I also work on the development and implementation of analytical protocols towards the quantification of specific metabolites.
Previously, I worked as a researcher at Center for Neuroscience and Cell Biology (CNC) - University of Coimbra until 2021 (2019-2021), in the field of omics strategies (proteomics and metabolomics) applied to the identification of biomarkers and early detection of psychiatric disorders, using MS-based methods. I have also worked 3 years as a postdoc researcher at EPAL - Empresa Portuguesa das Águas Livres S.A., Portugal, as part of the project "LIFE14 ENV/PT/000739 - Improving current barriers for controlling pharmaceuticals compounds in urban wastewater plants". My main activities were related with the development, validation and implementation of quantification protocols to measure pharmaceutical compounds present in biological, sludge and wastewater samples by LC-MS/MS. I also worked for 3 years as a postdoc researcher at CICECO and iBiMED - Department of Chemistry, University of Aveiro, Portugal as part of the project “New strategies applied to neuropathological disorders”. My main activities in this project were related with i) metabolomics and lipidomics studies in SH-SY5Y cells treated with a potential therapeutic agent for Alzheimer’s disease (AD) by NMR and MS-based methods; ii) conformational and dynamics studies using NMR and molecular dynamics (MD) simulations to assess the relationship between a specific group of therapeutic agents for AD (tripartite structures) and their BACE1 inhibitory activity; and iii) backbone assignment of proteins and macromolecules by multidimensional NMR methods. In addition, I also worked with other research groups towards the application of metabolomics to assess i) the influence of high pressure technology on the fermentation process of yogurts, ii) distinct winemaking processes, both studies using NMR; and iii) the metabolic profiling of signaling mutants in yeast to probe the relationship between quiescence entry and carbon metabolism.
Furthermore, I hold a PhD degree in Chemistry from CICECO-Department of Chemistry, University of Aveiro, Portugal, on the subject "Metabonomics studies to assess Beer quality and stability", concluded at 25 November 2011. During the PhD, my work was focused on the chemical characterization of liquid foods (mainly by NMR spectroscopy and MS-related methods) and in the development and application of statistical models towards high-throughput methodologies for food classification, identification of specific markers and the quantification of specific compounds present in complex matrices (mainly beer, but also wine, fruit juices and water).
Overall, the developed work allowed me to be co-author of 26 SCI papers (11 of them as first author, and 4 as corresponding author), 1 article in a proceedings of an international symposium and 3 book chapters in internationally recognized publishers. In addition, I am also co-author of 14 communications in international conference (6 of them oral presentation) and 5 oral presentations in national research meetings. Overall, I have an h-index of 10 and 409 citations (Scopus author identifier).
研究兴趣
论文共 21 篇作者统计合作学者相似作者
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Joao E. Rodrigues,Ana Martinho, Catia Santa,Nuno Madeira,Manuel Coroa, Vitor Santos, Maria J. Martins,Carlos N. Pato, Antonio Macedo, Bruno Manadas
Raquel S. Chaves,Daniel Salvador,Paulo Nogueira,Miguel M. Santos, Paula Aprisco,Célia Neto, Vítor Cardoso,Maria J. Benoliel,João E. Rodrigues,Rui N. Carneiro
Advances in Environmental and Engineering Researchno. 02 (2021): 1-1
Present and Future of High Pressure Processingpp.71-85, (2020)
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作者统计
#Papers: 32
#Citation: 496
H-Index: 11
G-Index: 22
Sociability: 5
Diversity: 0
Activity: 1
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