基本信息
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Bio
Prof. Lysaght's research group focus on a number of different areas around the central theme of cancer immunology and immunotherapy. Currently, a major research focus is investigating the impact and scheduling of chemotherapy and radiotherapy, and targeting immunometabolism to enhance anti-tumour immunity when used in combination with immunotherapies, namely immune checkpoint inhibitors. The majority of research in the cancer immunology and immunotherapy group is focused on upper gastrointestinal cancer, particularly oesophageal cancer but also gastric and pancreatic cancer. Research into how the regulation and trafficking of lymphocytes can be targeted to reduced adipose tissue and liver-associated inflammation is also a research interest within the group. Other areas of interest include identifying novel immunotherapeutic targets in the pre-malignant setting such as Barrett's Oesophagus and pancreatic cysts, which can be used to slow or prevent progression to malignancy. Another research interest is the area of obesity and cancer, and how this impacts anti-tumour immunity. Prof. Lysaght's group also investigates the role of adaptive immunity and obesity in the debilitating cancer-associated wasting disease cachexia and sarcopenia.
Research Interests
Papers共 180 篇Author StatisticsCo-AuthorSimilar Experts
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Brendan Moran,Andrew Sheppard, Aoife Kilgallon,Matthew Davey,John Reynolds,Joanne Lysaght,Noel Donlon
Mesentery and Peritoneum (2024)
Scientific reportsno. 1 (2024)
Cancer letters (2023): 216121-216121
Methods in molecular biology (Clifton, N.J.) (2023): 231-240
Jennifer Moran,Eimear Mylod,Laura E Kane, Caroline Marion, Emily Keenan,Marianna Mekhaeil,Joanne Lysaght,Kumlesh K Dev,Jacintha O'Sullivan,Melissa J Conroy
Frontiers in immunology (2023)
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Author Statistics
#Papers: 178
#Citation: 3409
H-Index: 31
G-Index: 57
Sociability: 6
Diversity: 3
Activity: 82
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