基本信息
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Bio
I am a Kidney Research UK Senior Fellow and group co-leader in the Transplantation Research Immunology Group (TRIG).
My research focuses on understanding the mechanisms of immunological tolerance versus immune activation with a view to developing therapies that could benefit transplant recipients and patients with immune related diseases. I am particularly interested in immune cells with regulatory properties, regulatory T cells (Treg) and myeloid-derived suppressor cells and the mechanisms of suppression utilized by these cells. By providing the data on the in vivo efficacy of ex vivo expanded human Treg, my research helped to inform the current clinical study; the TWO Study, in which we are testing safety and efficacy of Treg cells in kidney transplant recipients.
My research focuses on understanding the mechanisms of immunological tolerance versus immune activation with a view to developing therapies that could benefit transplant recipients and patients with immune related diseases. I am particularly interested in immune cells with regulatory properties, regulatory T cells (Treg) and myeloid-derived suppressor cells and the mechanisms of suppression utilized by these cells. By providing the data on the in vivo efficacy of ex vivo expanded human Treg, my research helped to inform the current clinical study; the TWO Study, in which we are testing safety and efficacy of Treg cells in kidney transplant recipients.
Research Interests
Papers共 113 篇Author StatisticsCo-AuthorSimilar Experts
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Weijie Du,Fatih Noyan,Oliver McCallion,Vanessa Drosdek,Jonas Kath,Viktor Glaser, Carla Fuster-Garcia, Mingxing Yang,Maik Stein,Olaf Weber,Julia K. Polansky,Toni Cathomen,
biorxiv(2024)
Nature (2024)
Transplantation (2024)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Amy R. Cross, Carlos E. de Andrea,Maria Villalba-Esparza, Manuel F. Landecho,Lucia Cerundolo,Praveen Weeratunga,Rachel E. Etherington,Laura Denney,Graham Ogg,Ling -Pei Ho, Ian S. D. Roberts,Joanna Hester,
TRANSPLANTATIONno. 12 (2023): 2464-2472
bioRxiv : the preprint server for biology (2023)
Fletcher C. E., Deng L., Orafidiya F.,Yuan W.,Lorentzen M. P. G. S., Cyran O. W., Varela-Carver A., Constantin T. A.,Leach D. A., Dobbs F. M.,Figueiredo I.,Gurel B.,
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Author Statistics
#Papers: 110
#Citation: 2257
H-Index: 23
G-Index: 46
Sociability: 6
Diversity: 3
Activity: 101
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