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Mechanisms and therapeutics for age-related retinal neurodegeneration
Key words: Macular degeneration, oxidative stress, iron transport, apoptosis, retina, aging, inflammation, transcriptomics
Description of Research
Age related macular degeneration (AMD) is the most common cause of irreversible blindness, yet its pathogenesis is poorly understood. Evidence suggests that cumulative oxidative damage contributes to AMD and aging in general. The Dunaief lab has found that AMD retinas have iron overload, which can cause oxidative stress. Increased understanding of retinal iron homeostasis may lead to treatments for AMD. To investigate the mechanisms of retinal iron regulation, the lab uses conditional knockout mouse models, human retinal tissue, and retinal cell tissue culture. A mouse line deficient in the iron transporting ferroxidases ceruloplasmin and hephaestin develops age-dependent retinal iron overload and retinal degeneration with features of AMD (Hahn et al., PNAS, 2004). Recent research in the lab indicates that inflammation promotes cellular iron overload in a vicious cycle leading to cell death. Our current focus is on the mechanisms of retinal iron homeostasis and development of therapeutics to protect the retina.
Research Interests
Mechanisms and therapeutics for age-related retinal neurodegeneration
Key words: Macular degeneration, oxidative stress, iron transport, apoptosis, retina, aging, inflammation, transcriptomics
Description of Research
Age related macular degeneration (AMD) is the most common cause of irreversible blindness, yet its pathogenesis is poorly understood. Evidence suggests that cumulative oxidative damage contributes to AMD and aging in general. The Dunaief lab has found that AMD retinas have iron overload, which can cause oxidative stress. Increased understanding of retinal iron homeostasis may lead to treatments for AMD. To investigate the mechanisms of retinal iron regulation, the lab uses conditional knockout mouse models, human retinal tissue, and retinal cell tissue culture. A mouse line deficient in the iron transporting ferroxidases ceruloplasmin and hephaestin develops age-dependent retinal iron overload and retinal degeneration with features of AMD (Hahn et al., PNAS, 2004). Recent research in the lab indicates that inflammation promotes cellular iron overload in a vicious cycle leading to cell death. Our current focus is on the mechanisms of retinal iron homeostasis and development of therapeutics to protect the retina.
Research Interests
Papers共 267 篇Author StatisticsCo-AuthorSimilar Experts
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Experimental Eye Research (2024): 109879-109879
Frontiers in ophthalmology (2023)
Frontiers in Ophthalmology (2023)
Disease models & mechanismsno. 7 (2023)
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCEno. 8 (2023)
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Experimental eye research (2023): 109772-109772
Frontiers in ophthalmology (2023)
Disease models & mechanismsno. 7 (2023)
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