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In the past several years, his work was focused on investigating regenerative biology of two major adult cardiac tissues: the myocardium and the epicardium. Using a new Cre-loxP mediated myocardial ablation approach, he and his colleagues showed that depleting up to 60% of myofibers in adult zebrafish heart caused classic indicators of heart failure: gasping, lethargy and reduced exercise capacity. They found that adult zebrafish can fully regenerate lost myocardium and reverse the signs of heart failure within several days, through massive cardiomyocyte proliferation detected throughout the heart. Using a new bacterial nitroreductase ablation system, He and his colleagues demonstrated that the epicardium is required for heart regeneration. Furthermore, their work showed that the epicardium itself has high capacity for renewal and fully regenerates even after 90% loss of epicardial cells.
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Cell Reportsno. 4 (2024)
Cell Reportsno. 4 (2024): 114092
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Cell reportsno. 4 (2024): 114092-114092
Cell Reportsno. 4 (2024): 114092
Nature Communicationsno. 1 (2023): 1-16
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