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Sensing and responding to the environment is critical for all living beings. Most sensory systems utilize cilia to sense stimuli and convert them into physiological responses.
Jinghua Hu, Ph.D., uses various model systems to study the correlation between cilia dysfunction and cilia-related diseases (collectively known as ciliopathies). The long-term goals of Dr. Hu's laboratory are to understand how cilia form and function; determine the pathogenesis underlying ciliopathies; and design therapies to prevent, delay or halt disease progression.
With rapid advancements during the past decade in the positional cloning of human disease genes, a wide variety of genetic disorders — such as autosomal dominant polycystic kidney disease (ADPKD), Bardet-Biedl syndrome, Joubert syndrome, nephronophthisis, Meckel-Gruber syndrome and autosomal recessive polycystic kidney disease — have been molecularly characterized as ciliopathies.
Because of the essential role of mammalian cilia in embryonic development, it is prohibitively difficult to study the functions of ciliopathy candidates in mammalian models. The highly conserved ciliopathy genes, ciliogenesis pathway and cilia sensory function of C. elegans make this organism a powerful model for characterizing the physiological roles of ciliary proteins in their native cellular environment.
The major experimental approaches used in Dr. Hu's laboratory include molecular genetics, biochemistry, real-time imaging and model organisms. Dr. Hu's research has been funded by the National Institutes of Health and PKD Foundation, among other organizations.
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论文共 63 篇作者统计合作学者相似作者
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Huicheng Chen,Zhimao Wu,Ziwei Yan,Chuan Chen, Yingying Zhang, Qiaoling Wang, Yuqing Gao,Kun Ling,Jinghua Hu,Qing Wei
ADVANCED SCIENCEpp.e2308820-e2308820, (2024)
Kai He, Xiaobo Sun,Chuan Chen, San Luc,Jielu Hao,Yingyi Zhang,Yan Huang,Haitao Wang,Kun Ling,Jinghua Hu
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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DIABETES (2023)
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Diabetesno. Supplement_1 (2023)
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