基本信息
views: 0
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
Bio
Jing Wang Resaerch Director INSERM and Group
Leader
Scientific expertise (please provide keywords/phrases for your research areas)
Molecular mechanisms of cochlear cell death linked to ototoxic drugs (CDDP or aminoglycosides), noise exposure, ageing and genetic factors; Cell death and repair pathways; DNA damage response; Oxidative stress; Apoptosis; Autophagy; Mitochondrial damage; Senescence; Pharmacological hearing rescue strategies against noise-, ototoxic drug-induced and age-related hearing loss; Gene therapies; Preclinical development of hearing protective drugs.
Dates Appointment
2019 to date Research Director, INSERM, France
2016 to date Invited Professor, University of Kunming, Chine
2006-2010 Senior Researcher, Institute of Neuroscience of Montpellier, France
2003-2006 Research director of preclinical development of D-JNKI-1 (AM-111), Auris Medical
Summary of research in recent years
My goal is to elucidate signaling pathways underlying the degeneration of cochlear neuro-epithelium in acquired (e.g. noise-, ototoxic drug-induced), age-related and genetic hearing loss using disease-specific model systems. My research group is drawing on multi-disciplinary approaches including electrophysiological approaches, electron microscopy and tomography, single qPCR and RNA-Seq analysis, viral gene transfer and recent gene mutation repair techniques to understand disease mechanisms and to rescue hearing loss. Our final goal is to restore hearing. Our studies have demonstrated that administration of pharmacological compounds can prevent sensory hair-cell death and restore auditory function in animal models of noise-induced hearing loss. These results lead to clinical trials, which are under development with pharmaceutical companies. Using viral gene transfer, we aim to restore hearing through replacement or repair of defective genes and to regenerate the hair cells in mouse models of human genetic and acquired deafness as well as in inner ear organoids generated from patient pluripotent stem cells.
Patents:
1. Patent (EP18306467). Methods and compositions for preventing and/or treating age-related hearing loss. Inventors : Wang J, Benkafadar N, François F, Puel, JL.
2. Patent (WO2017125429 A1). The use of a temporary inhibitor of p53 for preventing or reducing cancer relapse. Inventors: Wang J, Benkafadar N, Menardo J, Puel, JL.
3. Patent (WO 2007119098 A3). Methods for the treatment of tinnitus induced by cochlear excitotoxicity. Inventors: Guitton M, Puel JL, Pujol R, Ruel J, Wang J.
4. Patent (WO 2005092345 A1). Use of a phenothiazine derivative for preventing and/or treating hearing loss. Inventors : Pignol B, Puel JL, Auvin S, Chabrier de Lassauniere PE, Wang J.
Selected publications since 2017
Metrics
Google scholar h-Index: 32, 14763 citations, 58 publications, 105 communications orales and posters.
1. Affortit C, Blanc F, Nasr J, Ceccato JC, Markossian S, Guyot R, Flamant F, Puel JL and Wang J* (2022) A disease-associated mutation in thyroid hormone receptor α1 causes hearing loss and sensory hair cell patterning defects in mice. Science Signaling. 2022 accepted. (IF5years: 8.19) - *: auteur correspondant).
2. Gratias P, Nasr J, Affortit C, Ceccato JC, François F, Casas F, Pujol R, Pucheu S, Puel JL, Wang J* (2021) Impulse Noise Induced Hidden Hearing Loss, Hair Cell Ciliary Changes and Oxidative Stress in Mice. Antioxidants (Basel). Nov 25;10(12):1880. doi: 10.3390/antiox10121880. (IF5years: 6.312, ) - *: auteur correspondant).
3. Wang J, Serratrice N, Lee CJ, François F, Sweedler JV, Puel JL, Mothet JP, Jérôme Ruel J (2021) Physiopathological Relevance of D-Serine in the Mammalian Cochlea. Front Cell Neurosci. Dec, 15: 733004. doi: 10.3389/fncel.2021.733004. (IF5years: 5.505,) - *: auteur correspondant).
4. Blanc F, Bemelmans AP, Affortit C, Joséphine C, Puel JL, Mondain M and Wang J* (2021) A single cisterna magna injection of AAV leads to binaural transduction in mice. Front. Cell Dev. Biol. - Molecular and Cellular Pathology, DOI: 10.3389/fcell.2021.783504. (IF5years: 5.505, ) - *: auteur correspondant)
5. Ruel J, Guitton MJ, Gratias P, Lenoir M, Shen S, Puel JL, Brabet P and Wang J* (2021) Endogenous Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Plays a Protective Effect Against Noise-Induced Hearing Loss. Front Cell Neurosci. Mar 22;15: 658990. doi: 10.3389/fncel.2021.658990, eCollection.
6. Affortit C, Casas F, Ladrech S, Ceccato JC, Bourien J, Coyat C, Puel JL, Lenoir M and Wang J* (2021) Exacerbated age-related hearing loss in mice lacking the p43 mitochondrial T3 receptor. BMC Biol. 2021 Feb 1;19(1):18. doi: 10.1186/s12915-021-00953-1. (IF5years: 7.43) - *: auteur correspondant).
7. Bermúdez-Muñoz JM, Adelaida M Celaya AM, Hijazo-Pechero S, Wang J, Serrano M and Varela-Nieto I (2020) G6PD overexpres
Research Interests
Papers共 57 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Cellular and Molecular Life Sciencesno. 1 (2024): 1-22
Anissa Rym Saidia,Florence Francois,Francois Casas,Ilana Mechaly,Stephanie Venteo, Joseph T. Veechi,Jerome Ruel,Jean-Luc Puel,Jing Wang
ANTIOXIDANTSno. 2 (2024)
Health Sciences Review (2024): 100181
Cell death and diseaseno. 6 (2023)
Authorea (Authorea) (2022)
Load More
Author Statistics
#Papers: 54
#Citation: 2238
H-Index: 26
G-Index: 41
Sociability: 5
Diversity: 3
Activity: 18
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn