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Bio
Director, Center for Genome Engineering, Institute for Basic Science, 2014-present,
Current Research Interests :
We focus on developing programmable nucleases that enable genome editing in plants, animals, and cultured cells including human pluripotent stem cells. These nucleases cleave chromosomal DNA in a targeted manner, producing DNA double-strand breaks (DSBs), whose repair via endogenous mechanisms gives rise to targeted genome modification in cells and whole organisms. For the last ten years or so, we have developed three different types of programmable nucleases, namely, zinc finger nucleases (ZFNs), transcriptional activator-like effector nucleases (TALENs), and RNA-guided engineered nucleases (RGENs) derived from the type II CRISPR/Cas prokaryotic adaptive immune system. These nucleases are now used widely in almost every discipline in biology, biotechnology, and molecular medicine.
Representative Publications :
Kim H and Kim JS (2014) A guide to genome engineering with programmable nucleases. Nature Reviews Genetics 15, 321-334.
Bae S, et al. and Kim JS (2014) Microhomology-based choice of Cas9 nuclease target sites. Nature Methods 11, 705-706.
Kim YS et al. and Kim JS (2013) A library of TAL effector nucleases spanning the human genome. Nature Biotechnol. 31, 251. (Featured in Tools in Brief, Nature Methods 10, 286),
Cho SW et al. and Kim JS (2013) Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease. Nature Biotechnol. 31, 230. (Featured in News and Views, Nature 495, 50; Nat. Biotechnol. 31, 208; Nat. Methods 10, 189; and SciBX 6, 1),
Sung YH, et al. and Kim JS*, Lee HW* (2013) Knockout mice created by TALEN-mediated gene targeting. Nature Biotechnol. 31, 23. (* co-corresponding authors)
Research Interests
Papers共 537 篇Author StatisticsCo-AuthorSimilar Experts
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Nature Reviews Molecular Cell Biologyno. 1 (2023): 1-12
PLANT METHODSno. 1 (2023): 1-11
Journal of Animal Science and Technologyno. 5 (2023): 989-1001
FASTpp.379-393, (2023)
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Cancersno. 19 (2023): 4768-4768
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