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Bio
Decoding myeloid cell functions may hold the key to a cure for some diseases that are still devastating humanity, such as TB. Myeloid cells comprise a divers subpopulations that are either protective or permissive cells. My work is geared toward identifying myeloid subtypes with the polarizing roles in M. tuberculosis infection, and ultimately discovering host factors that determine host immunity and bacterial pathogenesis.
My strategy to improve host protective immune responses as follows:
1. identifying myeloid sub-populations that hamper protective host response using multi-color flow cytometry
2. Determining effector T cell efficacies on each myeloid subset to distinct protective and detrimental populations.
3. discovering targets responsible for suppression through gene chip analysis of the sub-populations
4. validating and testing target molecules for drug development
Having working on tuberculosis, I have identified a myeloid subset primarily responsible for bacterial growth and a set of genes are highly expressed in the subset. The goal of my study is to elucidate the role of the genes and develop a drug therapy that neutralize the supressive population.
Research Interests
Papers共 105 篇Author StatisticsCo-AuthorSimilar Experts
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Jin-Kyung Lee,Jinhee Lee,Moo-Kwon Chung, Taeksoo Shin, Ji Young Park,Kyoung-Joung Lee,Hyo-Sang Lim,Sangwon Hwang,Erdenebayar Urtnasan, Yongmie Jo,Min-Hyuk Kim
Nature communicationsno. 1 (2024): 5710-5710
Jeong Hun Yang, Yuree Chung,Sang Jin Rhee,Kyungtaek Park,Min Ji Kim, Hyunju Lee,Yoojin Song,Sang Yeol Lee,Se-Hoon Shim,Jung-Joon Moon,Seong-Jin Cho,Shin Gyeom Kim,
Journal of psychiatric research (2024): 442-451
Ji-Hee Kim,Kyu-Hee Hwang,Seong-Heon Kim, Hi-Ju Kim, Jung-Min Kim,Mi-Young Lee,Seung-Kuy Cha,Jinhee Lee
International journal of molecular sciencesno. 11 (2024): 6116
Jin-Kyung Lee,Min-Hyuk Kim,Sangwon Hwang,Kyoung-Joung Lee, Ji Young Park, Taeksoo Shin,Hyo-Sang Lim,Erdenebayar Urtnasan,Moo-Kwon Chung,Jinhee Lee
BMJ openno. 6 (2024): e073290-e073290
FRONTIERS IN PSYCHIATRY (2023): 1260295-1260295
Scientific Reportsno. 1 (2023): 1-9
Journal of Medical Virologyno. 2 (2023): e28354-e28354
JOURNAL OF BEHAVIORAL ADDICTIONS (2023): 328-328
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