Dr. Xiang’s lab is interested in studying cellular and molecular mechanisms for CD4 T cell help in CD8 cytotoxic T lymphocyte (CTL) responses and memory and developing novel exosome-targeted T cell-based immunotherapeutic vaccines for HER2-positive breast cancer and HIV-1 patients. Recently, Dr. Xiang’s group discovered the critical role of mannose-6-phosphate Receptor (M6PR) in regulation of T cell fate. Currently, his team is elucidating the molecular pathways for pro-survival cytokine-induced differential M6PR expression-regulated CTL contraction and memory.