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At that time, characterisation of the HLA (human leukocyte antigen) molecules responsible for tissue graft rejection was just beginning, eventually becoming known as MHC (major histocompatibility complex) molecules and found to have crucial roles in the detection and destruction of pathogens. He developed a biochemical purification protocol for some âcontaminantsâ in the HLA preparation, eventually showed that they were what became known as class II molecules, and used proteolysis and limited sequencing to define their domain structure. He realised that this domain organisation of class II molecules was similar to class I molecules but rearranged, and eventually described plausible scenarios for the evolution of their genes from a common ancestor, beginning a life-long fascination with the evolution of immunity.
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论文共 145 篇作者统计合作学者相似作者
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DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY (2023): 104966-104966
Feng Zhu,Zhong-Tao Yin,Qiang-Sen Zhao, Yun-Xiao Sun,Yu-Chen Jie,Jacqueline Smith,Yu-Ze Yang,David W. Burt,Maxwell Hincke,Zi-Ding Zhang, Meng-Di Yuan,Jim Kaufman,
Communications biologyno. 1 (2023): 1-15
Lingxia Han,Shaolian Wu, Ting Zhang,Weiyu Peng,Min Zhao,Can Yue,Wanxin Wen,Wenbo Cai,Min Li, Hans-Joachim Wallny,David W Avila,William Mwangi,
Journal of evolutionary biologyno. 6 (2023): 847-873
Lingxia Han,Shaolian Wu,Weiyu Peng,Min Zhao,Can Yue,Wanxin Wen,Wenbo Cai, Ting Zhang, Hans Joachim Wallny,David W. Avila,William Mwangi,Venugopal Nair,
biorxiv(2022)
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