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个人简介
Research Interests. single molecule biophysics, super-resolution imaging, cell division, gene regulation
Research Description. My laboratory focuses on developing novel single-molecule imaging and labeling tools in single cells to study the structures, functions and dynamics of macromolecular assemblies. For example, we pioneered the use of superresolution imaging and single-molecule tracking in microbiology to study bacterial cell division. We developed single-molecule gene expression reporting systems and chromosomal DNA conformation markers to probe the dynamics of gene regulation and transcription in bacterial cells. We also devote significant efforts to develop single-molecule imaging methods with new capacities to aid biological investigations in human cells, fluid and tissues. Our work is at the frontier of single-molecule single-cell biophysics, and has enabled new quantitative understandings of essential cellular processes including gene regulation and cell division.
Research Description. My laboratory focuses on developing novel single-molecule imaging and labeling tools in single cells to study the structures, functions and dynamics of macromolecular assemblies. For example, we pioneered the use of superresolution imaging and single-molecule tracking in microbiology to study bacterial cell division. We developed single-molecule gene expression reporting systems and chromosomal DNA conformation markers to probe the dynamics of gene regulation and transcription in bacterial cells. We also devote significant efforts to develop single-molecule imaging methods with new capacities to aid biological investigations in human cells, fluid and tissues. Our work is at the frontier of single-molecule single-cell biophysics, and has enabled new quantitative understandings of essential cellular processes including gene regulation and cell division.
研究兴趣
论文共 117 篇作者统计合作学者相似作者
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STAR PROTOCOLSno. 1 (2024): 102766-102766
NUCLEIC ACIDS RESEARCHno. 2 (2024): 724-737
MBIOno. 2 (2024): e0129023-e0129023
Longhua Hu, Amilcar Perez, Tanya Nesterova,Zhixin Lyu,Atsuhi Yahashiri,David S. Weisss,Jie Xiao,Jian Liu
biorxiv(2024)
Amilcar J. Perez,Jie Xiao
Current Opinion in Microbiology (2024): 102490-102490
Journal of Physical Chemistry Bno. 17 (2023): 3816-3828
Nature communicationsno. 1 (2023): 4585-4585
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