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Parvoviruses contain a small linear single-stranded DNA genome between 4.5-5.5 kb in length that has palindromic hairpin termini which serve as the origins of DNA replication. The viral genome is encapsidated within a non-enveloped, icosahedral virion, approximately 20 nm in diameter.
Parvoviruses that infect humans are 1) Human parvovirus B19 (B19V), which is the etiological agent of the fifth disease in children, several hematological disorders, including aplastic crisis and pure read cell aplasia, and hydrops fetalis in pregnant women; 2) Human bocavirus 1 (HBoV1) that causes lower respiratory tract infections in young children; and 3) Adeno-associated viruses (AAVs), which are non-pathogenic to humans and used as vectors for human gene therapy.
Qiu lab focuses on studying human parvoviruses B19V, HBoV1, and AAVs. The lab has chosen to investigate how these human parvoviruses utilize cellular DNA replication and DNA repair mechanisms for their DNA replication, how the viral genes are transcribed, processed, and translated to govern the production of progeny virions, and, for B19V and HBoV1, how the viral infections initiate, subvert the cellular defense mechanism, and eventually kill the infected cells. These fundamental studies will help understand the pathogenesis of human parvovirus infection, which will lead to identifying novel targets for the development of antiviral drugs to control viral infection and will also help to develop better parvoviral vectors for human gene therapy. Since the COVID-19 pandemic, we modulate SARS-CoV-2 infection of human airway epithelia and identify anti-virals.
Current ongoing projects:
1. Development of recombinant AAV and HBoV1 vectors for gene delivery into human airways.
2. Study of human virus infection in human airway epithelia.
3. Understanding molecular mechanisms of virus infection in human erythroid progenitors.
Parvoviruses that infect humans are 1) Human parvovirus B19 (B19V), which is the etiological agent of the fifth disease in children, several hematological disorders, including aplastic crisis and pure read cell aplasia, and hydrops fetalis in pregnant women; 2) Human bocavirus 1 (HBoV1) that causes lower respiratory tract infections in young children; and 3) Adeno-associated viruses (AAVs), which are non-pathogenic to humans and used as vectors for human gene therapy.
Qiu lab focuses on studying human parvoviruses B19V, HBoV1, and AAVs. The lab has chosen to investigate how these human parvoviruses utilize cellular DNA replication and DNA repair mechanisms for their DNA replication, how the viral genes are transcribed, processed, and translated to govern the production of progeny virions, and, for B19V and HBoV1, how the viral infections initiate, subvert the cellular defense mechanism, and eventually kill the infected cells. These fundamental studies will help understand the pathogenesis of human parvovirus infection, which will lead to identifying novel targets for the development of antiviral drugs to control viral infection and will also help to develop better parvoviral vectors for human gene therapy. Since the COVID-19 pandemic, we modulate SARS-CoV-2 infection of human airway epithelia and identify anti-virals.
Current ongoing projects:
1. Development of recombinant AAV and HBoV1 vectors for gene delivery into human airways.
2. Study of human virus infection in human airway epithelia.
3. Understanding molecular mechanisms of virus infection in human erythroid progenitors.
Research Interests
Papers共 211 篇Author StatisticsCo-AuthorSimilar Experts
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Journal of virologyno. 6 (2024): e0063324-e0063324
Kang Ning,Junxing Zhao,Zehua Feng,Soo Yeun Park, Shane McFarlin,Fang Cheng,Ziying Yan,Jingxin Wang,Jianming Qiu
Proceedings of the National Academy of Sciences of the United States of Americano. 25 (2024): e2320782121-e2320782121
JOURNAL OF VIROLOGYno. 3 (2024)
Xueyan Zhang,Jianhui Guo,Huanzhou Xu,Shuang Ding,Lishi Liu, Zhen Chen,Jingwen Yang, Yi Liu,Haojie Hao,Fang Huang,Jianming Qiu,Wuxiang Guan,
Journal of virologyno. 3 (2024): e0169523-e0169523
Siyuan Hao, Kang Ning, Cagla A. Kuz,Min Xiong,Wei Zou,Soo Y. Park, Shane McFarlin,Ziying Yan,Jianming Qiu
MOLECULAR THERAPYno. 4 (2023): 226-226
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Siyuan Hao,Xiujuan Zhang,Kang Ning,Zehua Feng,Soo Yeun Park,Cagla Aksu Kuz, Shane McFarlin, Donovan Richart,Fang Cheng,Elizabeth Yan Zhang,Aaron Zhang-Chen,Ziying Yan,
bioRxiv : the preprint server for biology (2023)
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