Jia-huai Wang
副教授
Department of Medical Oncology
Dana-Farber Cancer Institute;Department of Cancer Biology, Dana-Farber Cancer Institute;Department of Pediatrics, Harvard Medical School, Harvard University;Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Harvard University
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个人简介
Dr. Wang has been working on structural biology for several decades. His work includes insulin, plant toxins, RNA and DNA/protein complex. Over the last 30 years he has been focusing on structures of cell surface receptors that play critical roles in immune system and nervous system. In collaboration with colleagues within Dana-Farber and Harvard Medical School, he has worked out structures of a number of key immune molecules, including T cell receptors, MHC molecules, co-receptors and their interacting complexes. His group has also determined structures of many cell adhesion molecules, such as CD2, CD58, Cadherin, ICAM family members and the complexes with their interacting partners. More recently he begins to turn his interests into neuronal receptors. Drosophila Dscam is one example. The homophilic binding of Dscam is key to correct neuronal wiring process. Dr. Wang has organized an international collaboration to work on the molecular mechanism of axon guidance. Wang’s group has also been working on structural virology. The lab has solved structures of several virus receptors and HIV core fusion protein, gp41. In collaboration with colleagues at Hong Kong, a structure of nucleoprotein from H5N1 has been determined. More recently he began to explore the host control of HIV infection, working on structure basis of T cell immunity against HIV.
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Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2022)
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Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2022)
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2022)
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2021)
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