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Our research group is engaged in a wide variety of problems directed toward the total synthesis of pharmacologically active natural products. Several target molecules of current interest in the group are shown below. In addition to pursuing total synthesis the group is focused on developing novel synthetic methodology. For example, considerable effort has been committed to an investigation of chromium(0)-promoted higher-order cycloaddition reactions, which comprise a class of potentially very powerful transformations for constructing complex cyclic structures. Processes involving efficient [6π+4π] and [6π+2π] cycloadditions have been brought to practice recently in our laboratories, and targets such as the steroid, (+)-estradiol and the tropane alkaloid, (+)-ferruginine have been prepared using this technology. Most recently, a novel and very powerful chromium(0)-mediated multicomponent cycloaddition has been discovered in our laboratories which is proving to be an important addition to the synthetic armory. These multicomponent transformations are uniquely capable of producing rapid increases in molecular complexity, including the creation of considerable stereochemical information.
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论文共 170 篇作者统计合作学者相似作者
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ChemInformno. 34 (2013)
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#Papers: 169
#Citation: 4656
H-Index: 40
G-Index: 57
Sociability: 5
Diversity: 2
Activity: 0
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