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Associate Professor Jessica Mar's research group focuses on the development of bioinformatics methods to understand how regulatory processes go awry in human diseases. Specifically, the groups is interested in modelling how variability of gene expression contributes to regulation of the transcriptome. This interest has led us very naturally into single cell biology where there is a great need to develop accurate statistical approaches for data arising from single cell sequencing. Elucidating heterogeneity and variability in gene expression in this context in important as this may uncover new cellular subtypes or identify stochasticity in the usage of key pathway or master regulators.
The explosive availability of big data sets, coupled with the speed at which sequencing technologies have advanced have created an exciting environment for the current state of computational biology research. The Mar group looks to modern tools in statistics, such as Bayesian methodologies and machine learning algorithms, to make sense of biology from big data.
The explosive availability of big data sets, coupled with the speed at which sequencing technologies have advanced have created an exciting environment for the current state of computational biology research. The Mar group looks to modern tools in statistics, such as Bayesian methodologies and machine learning algorithms, to make sense of biology from big data.
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论文共 104 篇作者统计合作学者相似作者
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Mohammad Mahfuz Chowdhury, Samuel Zimmerman,Hannah Leeson,Christian Maximilian Nefzger,Jessica Cara Mar,Andrew Laslett,Jose Maria Polo,Ernst Wolvetang,Justin Cooper-White
Biomaterials Research (2024)
Atefeh Taherian Fard,Hannah C. Leeson,Julio Aguado,Giovanni Pietrogrande,Dominique Power,Cecilia Gomez-Inclan,Huiwen Zheng, Christopher B. Nelson,Farhad Soheilmoghaddam,Nick Glass, Malindrie Dharmaratne, Ebony R. Watson,
GEROSCIENCEno. 1 (2024): 999-1015
Zuen Ren,Malindrie Dharmaratne,Huizhi Liang,Outhiriaradjou Benard,Miriam Morales-Gallego,Kimita Suyama, Viney Kumar,Atefeh Taherian Fard, Ameya S. Kulkarni,Michael Prystowsky,Jessica C. Mar,Larry Norton,
BRITISH JOURNAL OF CANCER (2024)
Biomaterials research (2024): 0025-0025
biorxiv(2023)
biorxiv(2023)
Nature agingno. 12 (2023): 1561-1575
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