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His research deals with the chemistry, absorption, metabolism, and function of B vitamins, with primary emphasis on folate and vitamin B6 in human nutrition. An important aspect of his research has been the development and application of techniques involving stable-isotopic labeling to investigate folate and vitamin B6 bioavailability, metabolism and function in human subjects. Important outcomes of this work include: (1) data that led to revision of the recommended allowances for folate in human nutrition, (2) improved understanding of the bioavailability and metabolism of naturally occurring vitamin B6 glucosides, (3) data showing that the recently implemented fortification of cereal grain food products with folic acid is an effective way of delivering the vitamin in a stable and highly absorbable form; (4) improved understanding of the rates and pathways by which folate undergoes turnover in the human body, including during pregnancy and at various nutritional states; and (5) development of isotopic methods by the rates and fluxes of key phases of homocysteine and one-carbon metabolism can be determined in humans and animals. Application of these methods will yield new insight into nutritional and genetic effects on homocysteine/one-carbon metabolism.
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Papers共 331 篇Author StatisticsCo-AuthorSimilar Experts
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The Journal of nutritionno. 8 (2023): 2263-2273
Peter J. Aggett,Rylee T. Ahnen,Tolunay Beker Aydemir,Lynn B. Bailey, Lucien Bettendorff, William S. Blaner, Peggy R. Borum, Richard S. Bruno,Philip C. Calder,Marie A. Caudill,Samuel N. Cheuvront,Paul M. Coates,
Present Knowledge in Nutrition (2020)
Present Knowledge in Nutritionpp.225-237, (2020)
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