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Nuclear transcription factors, including androgen receptor (AR), estrogen receptor (ER), and glucocorticoid receptor (GR), play critical roles in the development of prostate and breast cancers and inflammatory responses. We found that a novel protein binds to AR and ER, and negatively regulates the transcriptional activities of AR and ER. We are trying to characterize the role of this protein in prostate and breast cancers and identify biomarkers of these cancers. We are also interested in GR transcriptional regulators that are involved in glucose metabolism. Atherosclerosis is a chronic inflammatory response of the vascular wall. We are attempting to understand the role of a novel transcription factor, the human small leucine zipper protein (sLZIP), in vascular smooth muscle cell (VSMC) migration and atherosclerosis progression. We found that sLZIPOE/+;LDLR-/- mice fed a high cholesterol diet exhibit enhanced arterial plaque formation and increased VSMC migration. We are studying whether sLZIP can be used as a therapeutic target molecule for treatment of atherosclerosis.
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Carcinogenesisno. 5 (2024): 300-310
Frontiers in Cell and Developmental Biology (2020)
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