基本信息
浏览量:466
职业迁徙
个人简介
My research program is divided into clinical investigation and basic research components. Clinical investigation approaches include studies aimed at identifying in vivo mechanisms underlying the pathogenesis of non-insulin dependent diabetes mellitus, obesity, and other disorders of insulin resistance. Studies are in progress to identify the relative role of each organ system (muscle, liver and fat) to the pathophysiology of NIDDM. In addition, a number of protocols are underway exploring new modes of therapy for established NIDDM as well as means of primary prevention for this disease. A major focus for the basic research program is to understand the molecular and cellular mechanisms of insulin and IGF-I action. An important emphasis is placed on understanding the structure/function relationship of the cognate receptors for these ligands. Approaches used include the use of site directed mutagenesis to modify the insulin and/or IGF-I receptor cDNAs followed by transfection of these modified cDNAs into host mammalian cells for biologic studies. Several functional domains of these receptor proteins have been identified which mediate the divergent and convergent signaling pathway of these two hormone receptor systems. For example, a domain of the insulin receptor has been identified which mediates the metabolic signaling properties of this receptor, whereas the other biologic effects of this receptor are intrinsic to other domains. The downstream signaling pathways of thee receptors are also under intensive investigation. These include studies of the mechanisms whereby insulin and IGF-I stimulate transcription of a series of early response genes and what are the signaling molecules which lie between the receptor and the DNA response elements which mediate these signaling pathways.
研究兴趣
论文共 754 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Michelle S Frei, Samantha A Sanchez,Longwei Liu,Falk Schneider,Zichen Wang, Hiroyuki Hakozaki,Yajuan Li,Anne C Lyons, Theresa V Rohm,Jerrold M Olefsky,Lingyan Shi,Johannes Schöneberg,
bioRxiv : the preprint server for biology (2024)
Annual review of physiology (2024): 225-253
Theresa V Rohm, Felipe Castellani Gomes Dos Reis,Roi Isaac, Cairo Murphy,Karina Cunha E Rocha,Gautam Bandyopadhyay,Hong Gao,Avraham M Libster,Rizaldy C Zapata,Yun Sok Lee,Wei Ying, Charlene Miciano,
Nature metabolismpp.1-19, (2024)
Natalie DeForest,Babu Kavitha,Siqi Hu,Roi Isaac,Lynne Krohn,Minxian Wang,Xiaomi Du, Camila De Arruda Saldanha, Jenny Gylys, Edoardo Merli,Ruben Abagyan,Laeya Najmi,
CELL GENOMICSno. 7 (2023): 100339-100339
Immunityno. 1 (2022): 31-55
Hong Gao,Zhongmou Jin,Gautam Bandyopadhyay,Karina Cunha E Rocha,Xiao Liu,Huayi Zhao,Dinghong Zhang, Hani Jouihan, Soheil Pourshahian,Tatiana Kisseleva,David A Brenner,Wei Ying,
medRxiv (Cold Spring Harbor Laboratory) (2022)
引用1浏览0引用
1
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn