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Hematopoietic stem cell transplantation provides effective therapy for patients with a variety of hematologic malignancies, but this continues to be a very intensive and potentially dangerous treatment approach. With recent improvements in supportive care, the most common causes of treatment failure are disease relapse and infectious complications associated with immune deficiency following transplant. To address these 2 issues, my laboratory research is focused on the characterization of immune reconstitution following allogeneic hematopoietic stem cell transplantation. It is now well established that reconstitution of donor hematopoiesis not only replaces the recipients own immune system but also results in the development of immunity against patient tumor cells. This development of anti-tumor immunity is very effective and plays an important role in the prevention of relapse following stem cell transplantation. Both laboratory projects and clinical trials are attempting to define the immunologic mechanisms as well as the target antigens of this response. With better understanding of the mechanisms and target specificity of the graft-versus-leukemia (GVL) response, it will be possible to distinguish GVL from graft-versus-host disease (GVHD) and to develop new methods for selectively enhancing GVL.
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Papers共 1075 篇Author StatisticsCo-AuthorSimilar Experts
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Terese C. Hammond,Marco A. Purbhoo,Sapana Kadel,Jerome Ritz,Sarah Nikiforow,Heather Daley,Kit Shaw, Koen van Besien,Alexandra Gomez-Arteaga,Don Stevens, Waldo Ortuzar,Xavier Michelet,
NATURE COMMUNICATIONSno. 1 (2024)
Alaa Ali, James D. Ham, Faten Zairi, Vaishvi Patel,Mubin Tarannum,Khanhlinh Dinh,Yasmin Abdulhamid,Juliana Vergara,Robert Soiffer,Jerome Ritz, John Beadle, Nikola A. Ivica,
Cancer Researchno. 6_Supplement (2024): 5231-5231
Transplantation and cellular therapyno. 7 (2024): 687.e1-687.e13
Nana Talvard-Balland, Lukas M Braun, Karen O Dixon, Melissa Zwick, Helena Engel, Alina Hartmann,Sandra Duquesne,Livius Penter,Geoffroy Andrieux, Lukas Simon Rindlisbacher,Andrea Acerbis, Jule Ehmann,
The Journal of clinical investigation (2024)
bioRxiv the preprint server for biology (2024)
Katie Maurer,Cameron Y Park, Shouvik Mani, Mehdi Borji, Crystal Shin, Wesley Lu,Haoxiang Lyu, Domenic Abbondanza, Chanell Mangum, Sachi Krishna,Samouil Farhi,Shuqiang Li,
Transplantation and Cellular Therapyno. 2 (2024): S256-S257
Terese C. Hammond,Marco A. Purbhoo,Sapana Kadel,Jerome Ritz,Sarah Nikiforow,Heather Daley,Kit Shaw, Koen van Besien,Alexandra Gomez-Arteaga,Don Stevens, Waldo Ortuzar,Xavier Michelet,
Nature Communicationsno. 1 (2024): 1-15
Shaobo Yang,Michal Sheffer, Isabel E Kaplan, Zongqi Wang,Mubin Tarannum,Khanhlinh Dinh,Yasmin Abdulhamid,Roman Shapiro, Rebecca Porter,Robert Soiffer,Jerome Ritz,John Koreth,
Research square (2024)
Conor Loy,Matthew P Cheng,Isabel H Gonzalez-Bocco,Joan Lenz, Emma Belcher,Andrew Bliss, Daniel Eweis-LaBolle,Tinyi Chu,Jerome Ritz,Iwijn De Vlaminck
medRxiv : the preprint server for health sciences (2024)
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