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个人简介
Since the start of my scientific career, I have been focused on the interaction of materials with tissue; more specifically on how cells and tissues respond to material surfaces with different properties in view of the development of a DNA-based coating for multiple advantageous properties of the DNA. In the early stage after finalization of my PhD-research, I dedicated my efforts to different aspects of optimizing the performance of bone regenerative materials via material modification, incorporation of biologicals, and (stem) cell-based strategies. With this work, I have obtained substantial expertise from both a material and a biological point of view using a plethora of techniques for material characterization and analysis of the biological response by cells (in vitro) and tissues (in vivo). Further, I have obtained ample experience with animal experimental work using a large variety of models in mice, rats, rabbits, guinea pigs, goats, sheep, dogs, and mini-pigs. Unpublished data further include a Phase I human clinical trial on the safety and performance of osteoinductive CaP granulate material in the sinus elevation procedure (with subsequent installment of dental implants) in the maxillary pre-molar region.
With the field of (bone) regenerative medicine as the revolutionary source for novel treatment modalities in the clinic, I anticipate that particularly knowledge on cell-material interactions will be instrumental for effective future bone defect treatments. Since the clinical use of cell- and growth factor-based strategies is bound to safety and regulatory concerns, the intrinsic property of materials that allow for control on cell and tissue responses will become a primary asset in the field of bone regeneration. As such, I have recently started to rationalize the concept of osteoinduction by CaPs via exploratory experiments on the effect of CaP coating composition on in vitro mineralization and in vivo bone responsesB as well as on effects of surface concavities on in vitro mineralizationA. The data of these submitted manuscripts in combination with collaborative work of researchers in the BioMedical Materials program project BONE-IP on CaPs have further triggered my interest in the fundamentals of cell-material interactions for the benefit of bone regenerative treatments. Additionally, my position within the Department of Biomaterials at the Radboud University Medical Center has allowed me to become established in the bone regenerative medicine scientific community to generate a network that enables current and future collaborative work.
研究兴趣
论文共 277 篇作者统计合作学者相似作者
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Jing Han, Jorine G.F. Sanders,Lea Andrée,Bart A.J.A. van Oirschot,Adelina S. Plachokova,Jeroen J.J.P. van den Beucken,Sander C. G. Leeuwenburgh,Fang Yang
crossref(2024)
Orthopaedic Proceedingsno. SUPP_7 (2023): 50-50
PLOS ONEno. 12 (2023): e0295076-e0295076
TISSUE ENGINEERING PART C-METHODSno. 7 (2023): 287-297
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCHno. 3 (2023): 490-501
TISSUE ENGINEERING PART Ano. 13-14 (2023)
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MATERIALS TODAY BIO (2023): 100889-100889
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