基本信息
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Bio
Breast cancer has been the focus of my research efforts for the past 20 years. As the Director of the Houston Methodist Hospital Cancer Center (HMCC) and Professor of Medicine at Weill Cornell Medical College (WCMC), I oversee the clinical trials, in particular breast cancer studies, conducted at HMCC. We have completed multiple federally funded biopsy-driven clinical trials, with a heavy emphasis on correlative studies. For example, as PI of a SPORE project we conducted a 170-patient randomized trial of docetaxel vs. Adriamycin/Cytoxan to discover unique gene expression patterns that predict sensitivity to these commonly used regimens. In support of these studies, we obtained additional funding from a Genomics Core Center of Excellence DoD grant. We conducted some of the earliest studies of human epidermal growth factor receptor 2 (HER2)-targeted neoadjuvant therapy, which was subsequently shown to almost double overall survival in early-stage breast cancer patients. We were the first to show that cancer stem cells are enriched in residual tumors following chemotherapy in human breast cancer patients. Unique to most of our clinical studies is the availability of human breast cancer biopsies from women undergoing therapeutic intervention. This has enabled us to investigate mechanisms of drug action and therapeutic resistance in an intact microenvironment and vasculature.
Research Interests
Papers共 565 篇Author StatisticsCo-AuthorSimilar Experts
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Research square (2024)
Nir Messer,Ryan C. Ellis,Sara M. Maskal,Jenny H. Chang,Ajita S. Prabhu,Benjamin T. Miller,Lucas RA. Beffa,Clayton C. Petro, Serrgio Mazzola Poli de Figueiredo,Aldo Fafaj,Varisha Essani,Michael J. Rosen
The American Journal of Surgeryno. Supplement_5 (2024): 99-104
CANCER RESEARCHno. 7 (2024)
AMERICAN SURGEONno. 6 (2024): 31348241241738-31348241241738
American Journal of Obstetrics and Gynecologyno. 1 (2024): S201
Harika Nagandla,Spyros Tastsoglou, Kim Cuong Cap, Aireana Phillips, Wei Qian,Jianying Zhou,Jenny Chang,Savitri Krishnamurthy, Naoto Ueno,Artemis Hatzigeorgiou,Christoforos Thomas
Cancer Researchno. 6_Supplement (2024): 6270-6270
American Journal of Obstetrics and Gynecologyno. 1 (2024): S390
Annals of surgery (2024)
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Author Statistics
#Papers: 552
#Citation: 23033
H-Index: 70
G-Index: 148
Sociability: 8
Diversity: 0
Activity: 8
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