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Virus and host determinants of viral pathogenesis
Alphaviruses are arthropod-borne positive sense RNA viruses that cause significant human and veterinary disease. Due to their ability to evolve rapidly, alphaviruses are important emerging and re-emerging viruses that pose threats to human and animal health.
In the Hyde lab we are interested in understanding how virus-host interactions contribute to and regulate pathogenesis of alphaviruses, as well as other positive-sense RNA (+ssRNA) viruses. In particular we are interested in understanding how viral RNA structure determines viral pathogenesis and regulates viral replication under a variety of conditions (e.g. different host species including mosquitoes and mammals, different temperatures, basal vs immune stimulated). We leverage comparisons of attenuated and pathogenic viruses (particularly Venezuelan equine encephalitis virus, VEEV) to define RNA structures and molecular mechanisms that contribute to emergence of pathogenic viruses.
Virus and host determinants of viral pathogenesis
Alphaviruses are arthropod-borne positive sense RNA viruses that cause significant human and veterinary disease. Due to their ability to evolve rapidly, alphaviruses are important emerging and re-emerging viruses that pose threats to human and animal health.
In the Hyde lab we are interested in understanding how virus-host interactions contribute to and regulate pathogenesis of alphaviruses, as well as other positive-sense RNA (+ssRNA) viruses. In particular we are interested in understanding how viral RNA structure determines viral pathogenesis and regulates viral replication under a variety of conditions (e.g. different host species including mosquitoes and mammals, different temperatures, basal vs immune stimulated). We leverage comparisons of attenuated and pathogenic viruses (particularly Venezuelan equine encephalitis virus, VEEV) to define RNA structures and molecular mechanisms that contribute to emergence of pathogenic viruses.
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论文共 19 篇作者统计合作学者相似作者
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Joshua M. Deerain,Turgut E. Aktepe, Alice M. Trenerry,Gregor Ebert,Jennifer L. Hyde, Katelyn Charry,Laura Edgington-Mitchell, Banyan Xu, Rebecca L. Ambrose,Soroush T. Sarvestani,Kate E. Lawlor,Jaclyn S. Pearson,
VIROLOGY (2024): 109921-109921
bioRxiv (Cold Spring Harbor Laboratory)no. 8 (2023): e0290675-e0290675
The Journal of infectious diseasesno. Suppl 6 (2023): S414-S426
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Sarah E. Hickson, Eden Brekke,Johannes Schwerk, Indraneel Saluhke,Shivam Zaver,Joshua Woodward,Ram Savan,Jennifer L. Hyde
biorxiv(2021)
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