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Nucleic acid aptamers offer a promising alternative to antibodies for a wide range of biosensing applications. We have demonstrated the use of a split aptamer to transduce a small molecule signal into the output of a DNA ligation event. If present in solution, the target molecule directs assembly of the split aptamer, bringing DNA-appended reactive groups into close proximity and thus promoting a chemical ligation. We have demonstrated that this enables the sensitive and selective detection of drug molecules in an enzyme-linked format, which is the current gold standard in clinical diagnostics. We have also addressed an overarching challenge in this field – the dearth of split aptamer recognition elements – by developing a reliable method for the engineering of aptamers into split aptamers.
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Angewandte Chemie (International ed. in English)no. 21 (2024): e202316678-e202316678
bioRxiv : the preprint server for biology (2024)
ACS Omegano. 40 (2023): 37442-37450
Colin S Swenson,Hector S Argueta-Gonzalez, Sierra A Sterling, Ryan Robichaux,Steve D Knutson,Jennifer M Heemstra
Trends in Chemistryno. 4 (2023): 245-248
Biomacromoleculesno. 4 (2023): 1934-1941
ACS MATERIALS LETTERSno. 6 (2023): 1565-1569
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