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Bio
Jennifer A. Philips is the Co-Director of the Infectious Diseases Division. Dr. Philips is principal investigator of an NIH-funded lab that studies how Mycobacterium tuberculosis evades the host immune response. M. tuberculosis causes TB, one of the world’s most deadly infections. It has infected humans for millenia and is highly adapted to navigate the complexities of the human immune system. The discoveries in the Philips laboratory have delineated how Mtb blocks lysosomal trafficking, alters host metabolism, and impairs antigen presentation. Her laboratory has identified clinically available drugs that restore the ability of the host to clear M. tuberculosis, overcoming key immune evasion strategies of Mtb. These findings may lead to novel host-directed therapies for TB. In recent unpublished work, they showed that the abundance of an M.tuberculosis-host co-metabolite in sputum and plasma distinguishes Mtb-infected patients from uninfected controls. This may enable development of biomarkers to individualize TB treatment. Thus, by making fundamental discoveries in Mtb pathogenesis, her group hopes to enable better therapies, novel biomarkers, and effective vaccines for one of humankind’s greatest afflictions.
Research Interests
Papers共 24 篇Author StatisticsCo-AuthorSimilar Experts
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Steven J. Grigsby, G. V. R. Krishna Prasad,Joshua B. Wallach,Ekansh Mittal,Fong-Fu Hsu,Dirk Schnappinger,Jennifer A. Philips
CELL REPORTSno. 1 (2024): 113607-113607
Bio-protocol (2023)
Cell reports methodsno. 8 (2022): 100267-100267
Pallavi Chandra,Li He,Matthew Zimmerman,Guozhe Yang,Stefan Köster,Mireille Ouimet, Han Wang, Kathyrn J. Moore,Véronique Dartois,Joel D. Schilling,Jennifer A. Philips
mBiono. 4 (2020)
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